{"id":18383,"date":"2019-05-20T09:26:47","date_gmt":"2019-05-20T07:26:47","guid":{"rendered":"https:\/\/www.mathsly.it\/wordpress\/?page_id=18383"},"modified":"2026-10-05T09:07:23","modified_gmt":"2026-10-05T07:07:23","slug":"servizi","status":"publish","type":"page","link":"https:\/\/www.mathsly.it\/wordpress\/servizi\/","title":{"rendered":"Servizi"},"content":{"rendered":"\n<!-- ============================================================\n  MATHSLY RESEARCH \u2014 Pagina Servizi\n  Aggiornamento giugno 2026: Fraunces, sfondo bianco\/grigio\n  Update luglio 2026: gerarchia servizi core \/ sviluppo \/ periferia\n============================================================ -->\n\n<link rel=\"preconnect\" href=\"https:\/\/fonts.googleapis.com\">\n<link rel=\"preconnect\" href=\"https:\/\/fonts.gstatic.com\" crossorigin=\"\">\n<link href=\"https:\/\/fonts.googleapis.com\/css2?family=Fraunces:ital,opsz,wght@0,9..144,400;0,9..144,600;0,9..144,700;1,9..144,400;1,9..144,600;1,9..144,700&amp;family=DM+Sans:wght@300;400;500;600&amp;display=swap\" rel=\"stylesheet\">\n\n<style>\n.msv *, .msv *::before, .msv *::after { box-sizing: border-box; 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color: var(--teal-lt); }\n.msv-btn.sm { padding: 8px 16px; font-size: 13px; }\n.msv-reveal { opacity: 0; transform: translateY(14px); transition: opacity .55s cubic-bezier(.22,1,.36,1), transform .55s cubic-bezier(.22,1,.36,1); }\n.msv-reveal.up { opacity: 1; transform: none; }\n.msv-reveal.d1 { transition-delay: .07s; }\n.msv-reveal.d2 { transition-delay: .14s; }\n.msv-reveal.d3 { transition-delay: .21s; }\n.msv-lcp { opacity: 1 !important; transform: none !important; transition: none !important; }\n.msv-geo { position: absolute; width: 1px; height: 1px; overflow: hidden; clip: rect(0,0,0,0); white-space: nowrap; }\n\n\/* \u2500\u2500\u2500 HERO \u2500\u2500\u2500 *\/\n.msv-s1 { background: var(--navy); position: relative; overflow: hidden; }\n.msv-s1::before { content: ''; position: absolute; inset: 0; pointer-events: none; background-image: linear-gradient(rgba(255,255,255,.018) 1px, transparent 1px), linear-gradient(90deg, rgba(255,255,255,.018) 1px, transparent 1px); background-size: 64px 64px; 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border: 1px solid rgba(255,255,255,.08); border-radius: 12px; overflow: hidden; }\n.msv-idx-head { padding: 14px 20px; border-bottom: 1px solid rgba(255,255,255,.07); font-size: 10px; font-weight: 600; letter-spacing: .14em; text-transform: uppercase; color: rgba(255,255,255,.35); }\n.msv-idx-group-label { padding: 10px 20px 6px; font-size: 9px; font-weight: 700; letter-spacing: .16em; text-transform: uppercase; color: rgba(34,159,164,.55); border-top: 1px solid rgba(255,255,255,.05); }\n.msv-idx-group-label:first-of-type { border-top: none; }\n.msv-idx-row { display: flex; align-items: center; gap: 12px; padding: 10px 20px; border-bottom: 1px solid rgba(255,255,255,.04); text-decoration: none; transition: background .2s; }\n.msv-idx-row:last-child { border-bottom: none; }\n.msv-idx-row:hover { background: rgba(255,255,255,.06); }\n.msv-idx-ico { width: 28px; height: 28px; border-radius: 6px; background: rgba(34,159,164,.15); display: flex; align-items: center; justify-content: center; font-size: 12px; flex-shrink: 0; }\n.msv-idx-row.periph .msv-idx-ico { background: rgba(255,255,255,.06); }\n.msv-idx-name { flex: 1; font-size: 13px; font-weight: 500; color: rgba(255,255,255,.75); }\n.msv-idx-row.periph .msv-idx-name { color: rgba(255,255,255,.45); font-weight: 400; }\n.msv-idx-arr { font-size: 12px; color: rgba(34,159,164,.60); transition: transform .2s; }\n.msv-idx-row:hover .msv-idx-arr { transform: translateX(3px); color: var(--teal-lt); }\n\n\/* \u2500\u2500\u2500 TARGET \u2500\u2500\u2500 *\/\n.msv-s2 { background: var(--white); border-bottom: 1px solid var(--border); }\n.msv-s2-wrap { padding: 88px 8vw; max-width: 1240px; margin: 0 auto; }\n.msv-s2-head { margin-bottom: 40px; }\n.msv-s2-head .msv-title.xl { color: var(--navy); margin: 12px 0; }\n.msv-s2-head .msv-title.xl em { font-style: italic; color: var(--teal); }\n.msv-s2-head p { font-size: 16px; line-height: 1.8; color: var(--ink-2); max-width: 580px; }\n.msv-targets { display: grid; grid-template-columns: repeat(4, 1fr); gap: 14px; }\n.msv-tgt { background: var(--bg); border: 1px solid var(--border); border-radius: 10px; padding: 24px 20px; text-decoration: none; display: flex; flex-direction: column; transition: border-color .2s, transform .2s; }\n.msv-tgt:hover { border-color: var(--border-s); transform: translateY(-2px); }\n.msv-tgt-ico { font-size: 22px; margin-bottom: 12px; }\n.msv-tgt-name { font-family: \"Fraunces\", serif; font-size: 14px; font-weight: 600; color: var(--navy); line-height: 1.3; margin-bottom: 8px; letter-spacing: -.01em; }\n.msv-tgt-desc { font-size: 13px; line-height: 1.6; color: var(--ink-2); flex: 1; margin-bottom: 12px; }\n.msv-tgt-arr { font-size: 12px; color: var(--teal); font-weight: 600; }\n\n\/* \u2500\u2500\u2500 GRIGLIA SERVIZI \u2500\u2500\u2500 *\/\n.msv-s3 { background: var(--bg); border-bottom: 1px solid var(--border); }\n.msv-s3-wrap { padding: 88px 8vw; max-width: 1240px; margin: 0 auto; }\n\n\/* separatori di blocco *\/\n.msv-block { margin-bottom: 56px; }\n.msv-block:last-child { margin-bottom: 0; }\n.msv-block-header { display: flex; align-items: baseline; justify-content: space-between; gap: 24px; margin-bottom: 20px; padding-bottom: 16px; border-bottom: 1px solid var(--border); }\n.msv-block-header h3 { font-family: \"Fraunces\", serif; font-size: 13px; font-weight: 600; letter-spacing: .12em; text-transform: uppercase; color: var(--navy); }\n.msv-block-header p { font-size: 13px; color: var(--ink-3); }\n\n\/* card standard *\/\n.msv-grid { display: grid; grid-template-columns: repeat(2, 1fr); gap: 14px; }\n.msv-card { background: var(--white); border: 1px solid var(--border); border-radius: 10px; padding: 24px 22px; display: flex; flex-direction: column; transition: border-color .2s, transform .2s; }\n.msv-card:hover { border-color: var(--border-s); transform: translateY(-2px); }\n.msv-card-tag { font-size: 10px; font-weight: 600; letter-spacing: .12em; text-transform: uppercase; color: var(--teal); margin-bottom: 8px; }\n.msv-card-title { font-family: \"Fraunces\", serif; font-size: 17px; font-weight: 600; color: var(--navy); line-height: 1.2; margin-bottom: 10px; letter-spacing: -.01em; }\n.msv-card-desc { font-size: 14px; line-height: 1.75; color: var(--ink-2); margin-bottom: 14px; flex: 1; }\n.msv-card-list { list-style: none; padding: 0; display: flex; flex-direction: column; gap: 6px; margin-bottom: 18px; }\n.msv-card-list li { display: flex; align-items: flex-start; gap: 8px; font-size: 13px; line-height: 1.5; color: var(--ink-2); }\n.msv-card-list li::before { content: '\u2192'; color: var(--teal); font-size: 11px; margin-top: 2px; flex-shrink: 0; font-weight: 600; }\n.msv-card-foot { display: flex; gap: 8px; flex-wrap: wrap; padding-top: 14px; border-top: 1px solid var(--border); margin-top: auto; }\n\n\/* card sviluppo \u2014 bordo teal sottile a sinistra *\/\n.msv-card.sviluppo { border-left: 3px solid rgba(34,159,164,.35); }\n\n\/* card periferia \u2014 compatte, sfondo leggermente diverso *\/\n.msv-grid.compact { grid-template-columns: repeat(3, 1fr); gap: 10px; }\n.msv-card.compact { background: var(--bg); padding: 18px 16px; }\n.msv-card.compact .msv-card-title { font-size: 14px; margin-bottom: 6px; }\n.msv-card.compact .msv-card-desc { font-size: 13px; margin-bottom: 10px; }\n.msv-card.compact .msv-card-list { display: none; }\n.msv-card.compact .msv-card-foot { padding-top: 10px; }\n\n\/* sezione header principale *\/\n.msv-s3-header { display: flex; justify-content: space-between; align-items: center; margin-bottom: 48px; padding-bottom: 24px; border-bottom: 2px solid var(--border); gap: 24px; }\n.msv-s3-header .msv-title.xl { color: var(--navy); }\n.msv-s3-header .msv-title.xl em { font-style: italic; color: var(--teal); }\n\n\/* \u2500\u2500\u2500 DIFFERENZIATORI \u2500\u2500\u2500 *\/\n.msv-s4 { background: var(--white); border-bottom: 1px solid var(--border); }\n.msv-s4-wrap { padding: 88px 8vw; max-width: 1240px; margin: 0 auto; }\n.msv-s4-head { margin-bottom: 40px; }\n.msv-s4-head .msv-title.xl { color: var(--navy); margin: 12px 0 12px; }\n.msv-s4-head .msv-title.xl em { font-style: italic; color: var(--teal); }\n.msv-s4-head p { font-size: 16px; line-height: 1.8; color: var(--ink-2); max-width: 580px; }\n.msv-diffs { display: grid; grid-template-columns: repeat(2, 1fr); gap: 14px; }\n.msv-diff { background: var(--bg); border: 1px solid var(--border); border-left: 3px solid var(--teal); border-radius: 0 10px 10px 0; padding: 24px 22px; transition: border-color .2s, transform .2s; }\n.msv-diff:hover { transform: translateX(3px); }\n.msv-diff-n { font-size: 10px; font-weight: 600; letter-spacing: .12em; text-transform: uppercase; color: var(--teal); margin-bottom: 6px; }\n.msv-diff-title { font-family: \"Fraunces\", serif; font-size: 16px; font-weight: 600; color: var(--navy); line-height: 1.2; margin-bottom: 10px; letter-spacing: -.01em; }\n.msv-diff-desc { font-size: 14px; line-height: 1.75; color: var(--ink-2); }\n.msv-diff-desc strong { color: var(--navy); font-weight: 600; }\n\n\/* \u2500\u2500\u2500 GARANZIA DI PROCESSO \u2500\u2500\u2500 *\/\n.msv-s4b { background: var(--navy); border-bottom: 1px solid rgba(255,255,255,.06); }\n.msv-s4b-wrap { padding: 88px 8vw; max-width: 1240px; margin: 0 auto; }\n.msv-s4b-head { margin-bottom: 48px; }\n.msv-s4b-head .msv-title.xl { color: var(--white); margin: 12px 0 12px; }\n.msv-s4b-head .msv-title.xl em { font-style: italic; color: var(--teal-lt); }\n.msv-s4b-head p { font-size: 16px; line-height: 1.8; color: rgba(255,255,255,.50); max-width: 580px; }\n.msv-guar { display: grid; grid-template-columns: repeat(3, 1fr); gap: 16px; }\n.msv-guar-card { background: rgba(255,255,255,.04); border: 1px solid rgba(255,255,255,.09); border-radius: 12px; padding: 32px 28px; position: relative; transition: background .2s; }\n.msv-guar-card:hover { background: rgba(255,255,255,.07); }\n.msv-guar-num { font-size: 11px; font-weight: 700; letter-spacing: .14em; text-transform: uppercase; color: rgba(34,159,164,.65); margin-bottom: 18px; }\n.msv-guar-icon { font-size: 28px; margin-bottom: 16px; }\n.msv-guar-title { font-family: \"Fraunces\", serif; font-size: 18px; font-weight: 600; color: var(--white); line-height: 1.2; margin-bottom: 12px; letter-spacing: -.02em; }\n.msv-guar-desc { font-size: 14px; line-height: 1.75; color: rgba(255,255,255,.55); }\n.msv-guar-desc strong { color: rgba(255,255,255,.85); font-weight: 600; }\n.msv-guar-tag { display: inline-block; margin-top: 16px; padding: 5px 12px; background: rgba(34,159,164,.15); border: 1px solid rgba(34,159,164,.25); border-radius: 3px; font-size: 11px; font-weight: 600; letter-spacing: .10em; text-transform: uppercase; color: var(--teal-lt); }\n@media (max-width: 1024px) { .msv-guar { grid-template-columns: 1fr; } }\n\n\/* \u2500\u2500\u2500 TEMPI E PREZZI \u2500\u2500\u2500 *\/\n.msv-s5 { background: var(--bg); border-bottom: 1px solid var(--border); }\n.msv-s5-wrap { padding: 88px 8vw; max-width: 1240px; margin: 0 auto; }\n.msv-s5-head { margin-bottom: 40px; }\n.msv-s5-head .msv-title.xl { color: var(--navy); margin: 12px 0 12px; }\n.msv-s5-head .msv-title.xl em { font-style: italic; color: var(--teal); }\n.msv-s5-head p { font-size: 16px; line-height: 1.8; color: var(--ink-2); max-width: 580px; }\n.msv-split { display: grid; grid-template-columns: 1fr 1fr; gap: 20px; }\n.msv-panel { background: var(--white); border: 1px solid var(--border); border-radius: 10px; padding: 28px 24px; }\n.msv-panel-label { font-size: 10px; font-weight: 600; letter-spacing: .14em; text-transform: uppercase; color: var(--teal); margin-bottom: 6px; }\n.msv-panel-title { font-family: \"Fraunces\", serif; font-size: 18px; font-weight: 600; color: var(--navy); line-height: 1.2; margin-bottom: 20px; letter-spacing: -.01em; }\n.msv-timesrow { display: flex; justify-content: space-between; align-items: flex-start; padding: 14px 0; border-bottom: 1px solid var(--border); gap: 12px; }\n.msv-timesrow:last-child { border-bottom: none; }\n.msv-times-n { font-size: 14px; font-weight: 500; color: var(--navy); flex: 1; line-height: 1.4; }\n.msv-times-std { font-size: 12px; color: var(--ink-2); margin-top: 2px; }\n.msv-times-std strong { color: var(--teal); font-weight: 600; }\n.msv-times-urg { font-size: 11px; color: var(--ink-3); margin-top: 1px; font-style: italic; }\n.msv-times-urg strong { color: var(--gold); font-weight: 600; font-style: normal; }\n.msv-pricerow { display: flex; justify-content: space-between; align-items: baseline; padding: 14px 0; border-bottom: 1px solid var(--border); gap: 12px; }\n.msv-pricerow:last-child { border-bottom: none; }\n.msv-price-name { font-size: 13px; font-weight: 500; color: var(--ink); flex: 1; line-height: 1.4; }\n.msv-price-val { font-family: \"Fraunces\", serif; font-size: 18px; font-weight: 700; color: var(--navy); white-space: nowrap; letter-spacing: -.01em; }\n.msv-price-val small { font-size: 11px; font-weight: 400; color: var(--ink-3); margin-right: 3px; font-family: \"DM Sans\", sans-serif; }\n.msv-price-frame { margin-top: 20px; padding: 14px 16px; background: var(--bg); border-radius: 8px; font-size: 13px; line-height: 1.65; color: var(--ink-2); border-left: 3px solid var(--gold); }\n.msv-price-frame strong { color: var(--navy); font-weight: 600; }\n\n\/* \u2500\u2500\u2500 FAQ \u2500\u2500\u2500 *\/\n.msv-s6 { background: var(--navy); }\n.msv-s6-wrap { padding: 88px 8vw; max-width: 1240px; margin: 0 auto; }\n.msv-s6-head { margin-bottom: 40px; }\n.msv-s6-head .msv-title.xl { color: var(--white); margin: 12px 0 12px; }\n.msv-s6-head .msv-title.xl em { font-style: italic; color: var(--teal-lt); }\n.msv-s6-head p { font-size: 16px; line-height: 1.8; color: rgba(255,255,255,.50); max-width: 580px; }\n.msv-faq { background: rgba(255,255,255,.04); border: 1px solid rgba(255,255,255,.08); border-radius: 10px; margin-bottom: 8px; overflow: hidden; transition: background .2s; }\n.msv-faq:hover { background: rgba(255,255,255,.06); }\n.msv-faq summary { list-style: none; padding: 20px 22px; font-size: 15px; font-weight: 600; color: var(--white); cursor: pointer; display: flex; justify-content: space-between; align-items: center; gap: 14px; user-select: none; font-family: \"Fraunces\", serif; letter-spacing: -.01em; }\n.msv-faq summary::-webkit-details-marker { display: none; }\n.msv-faq-icon { font-size: 20px; font-weight: 300; color: var(--teal-lt); transition: transform .25s; flex-shrink: 0; }\n.msv-faq[open] .msv-faq-icon { transform: rotate(45deg); }\n.msv-faq-body { padding: 0 22px 18px; font-size: 14px; line-height: 1.8; color: rgba(255,255,255,.60); }\n.msv-faq-body strong { color: var(--white); font-weight: 600; }\n\n\/* \u2500\u2500\u2500 CTA \u2500\u2500\u2500 *\/\n.msv-s7 { background: var(--bg); border-top: 1px solid var(--border); }\n.msv-s7-bar { position: absolute; top: 0; left: 0; right: 0; height: 3px; background: linear-gradient(90deg, var(--teal), var(--gold), var(--teal)); }\n.msv-s7-wrap { padding: 88px 8vw; max-width: 1240px; margin: 0 auto; display: grid; grid-template-columns: 1fr 1fr; gap: 64px; align-items: center; position: relative; }\n.msv-s7-left .msv-title.lg { color: var(--navy); margin: 12px 0 14px; }\n.msv-s7-left .msv-title.lg em { font-style: italic; color: var(--teal); }\n.msv-s7-left p { font-size: 16px; line-height: 1.8; color: var(--ink-2); margin-bottom: 24px; max-width: 400px; }\n.msv-s7-btns { display: flex; flex-wrap: wrap; gap: 10px; }\n.msv-s7-right { display: grid; grid-template-columns: 1fr 1fr; gap: 12px; }\n.msv-feat { background: var(--white); border: 1px solid var(--border); border-radius: 10px; padding: 18px; }\n.msv-feat-title { font-family: \"Fraunces\", serif; font-size: 13px; font-weight: 600; color: var(--navy); margin-bottom: 4px; }\n.msv-feat-desc { font-size: 12px; line-height: 1.6; color: var(--ink-2); }\n\n@media (max-width: 1024px) {\n  .msv-s1-wrap { grid-template-columns: 1fr; padding-top: 72px; }\n  .msv-svc-index { display: none; }\n  .msv-s3-header { flex-direction: column; align-items: flex-start; }\n  .msv-targets { grid-template-columns: 1fr 1fr; }\n  .msv-diffs { grid-template-columns: 1fr; }\n  .msv-split { grid-template-columns: 1fr; }\n  .msv-s7-wrap { grid-template-columns: 1fr; gap: 48px; }\n  .msv-grid.compact { grid-template-columns: 1fr 1fr; }\n}\n@media (max-width: 768px) {\n  .msv-s1-wrap, .msv-s2-wrap, .msv-s3-wrap, .msv-s4-wrap, .msv-s4b-wrap, .msv-s5-wrap, .msv-s6-wrap, .msv-s7-wrap { padding: 64px 5vw; }\n  .msv-grid, .msv-grid.compact { grid-template-columns: 1fr; }\n  .msv-targets { grid-template-columns: 1fr; }\n  .msv-s7-right { grid-template-columns: 1fr; }\n}\n<\/style>\n\n<div class=\"msv\">\n\n  <div style=\"position:relative;\">\n    <p class=\"msv-geo\">Mathsly Research offre consulenza statistica e biostatistica indipendente per ricerca clinica, pharma, CRO, IRCCS e accademia. Fondata da Maril\u00f9 Garo (matematico, 90+ pubblicazioni peer-reviewed, H-index 14 Scopus). Primo feedback entro 24 ore. Email: info@mathsly.it. Servizi: biostatistica per studi clinici (SAP ICH E9\/E9(R1), RCT, RWE, TLF per CSR), revisioni sistematiche e meta-analisi (PRISMA 2020, GRADE, NMA, PROSPERO), medical writing (CONSORT, STROBE, EQUATOR, risposta reviewer), protocolli di ricerca e SAP, data management, econometria (DiD, RDD, IV, panel), machine learning (TRIPOD, PROBAST), validazione statistica modelli AI per pharma (TRIPOD+AI, EMA, FDA SaMD), dispositivi medici (MDR, IVDR, FDA 510k, CLSI), statistica industriale (SPC, Gauge R&amp;R, DOE, ISO 9001, GMP), statistica forense e medico-legale (nesso causale, perdita di chance, Bradford Hill). Software: Stata, R, Python. Analisi di fattibilit\u00e0 senza impegno entro 24 ore.<\/p>\n  <\/div>\n\n  <!-- HERO -->\n  <section class=\"msv-s1\">\n    <div class=\"msv-s1-bar\"><\/div>\n    <div class=\"msv-glow a\"><\/div>\n    <div class=\"msv-glow b\"><\/div>\n    <div class=\"msv-s1-wrap\">\n      <div>\n        <div class=\"msv-eyebrow light msv-reveal\">Servizi di consulenza<\/div>\n        <h1 class=\"msv-title hero msv-s1-title msv-lcp\">Dalla progettazione alla pubblicazione. <em>Un referente unico.<\/em><\/h1>\n        <p class=\"msv-s1-sub msv-lcp\">Mathsly Research affianca pharma, CRO, IRCCS e gruppi di ricerca nella progettazione, analisi e pubblicazione di studi scientifici \u2014 con deliverable ICH-GCP, CONSORT, TRIPOD e PRISMA-compliant. SAP, systematic review, medical writing e advisory indipendente, con primo feedback entro 24 ore.<\/p>\n        <div class=\"msv-s1-btns msv-reveal d1\">\n          <a class=\"msv-btn solid\" href=\"https:\/\/www.mathsly.it\/wordpress\/contatti\/\">Parliamo del tuo progetto<\/a>\n          <a class=\"msv-btn outline-light\" href=\"https:\/\/www.mathsly.it\/wordpress\/prenotazione-appuntamento\/\">Prenota una call \u2192<\/a>\n        <\/div>\n      <\/div>\n      <!-- Indice con gruppi -->\n      <div class=\"msv-svc-index msv-reveal d2\">\n        <div class=\"msv-idx-head\">I nostri servizi<\/div>\n\n        <div class=\"msv-idx-group-label\">Core<\/div>\n        <a class=\"msv-idx-row\" href=\"#svc-clinica\"><div class=\"msv-idx-ico\">&#x1f52c;<\/div><span class=\"msv-idx-name\">Studi Clinici e Biostatistica<\/span><span class=\"msv-idx-arr\">\u2192<\/span><\/a>\n        <a class=\"msv-idx-row\" href=\"#svc-meta\"><div class=\"msv-idx-ico\">&#x1f4ca;<\/div><span class=\"msv-idx-name\">Systematic Review e Meta-analisi<\/span><span class=\"msv-idx-arr\">\u2192<\/span><\/a>\n        <a class=\"msv-idx-row\" href=\"#svc-writing\"><div class=\"msv-idx-ico\">&#x1f4dd;<\/div><span class=\"msv-idx-name\">Medical Writing<\/span><span class=\"msv-idx-arr\">\u2192<\/span><\/a>\n        <a class=\"msv-idx-row\" href=\"#svc-protocolli\"><div class=\"msv-idx-ico\">&#x1f4cb;<\/div><span class=\"msv-idx-name\">Protocolli di Ricerca e SAP<\/span><span class=\"msv-idx-arr\">\u2192<\/span><\/a>\n        <a class=\"msv-idx-row\" href=\"#svc-dispositivi\"><div class=\"msv-idx-ico\">&#x1f3e5;<\/div><span class=\"msv-idx-name\">Dispositivi Medici \u2014 MDR &amp; IVDR<\/span><span class=\"msv-idx-arr\">\u2192<\/span><\/a>\n\n        <div class=\"msv-idx-group-label\">Also Specialized<\/div>\n        <a class=\"msv-idx-row\" href=\"#svc-advisory\"><div class=\"msv-idx-ico\">&#x2696;&#xfe0f;<\/div><span class=\"msv-idx-name\">Advisory Indipendente &amp; IDMC<\/span><span class=\"msv-idx-arr\">\u2192<\/span><\/a>\n        <a class=\"msv-idx-row\" href=\"#svc-ai\"><div class=\"msv-idx-ico\">&#x1f9e0;<\/div><span class=\"msv-idx-name\">Validazione Statistica Modelli AI<\/span><span class=\"msv-idx-arr\">\u2192<\/span><\/a>\n        <a class=\"msv-idx-row\" href=\"#svc-forense\"><div class=\"msv-idx-ico\">&#x1f50e;<\/div><span class=\"msv-idx-name\">Statistica Forense e Medico-Legale<\/span><span class=\"msv-idx-arr\">\u2192<\/span><\/a>\n\n        <div class=\"msv-idx-group-label\">Extended Services<\/div>\n        <a class=\"msv-idx-row periph\" href=\"#svc-altro\"><div class=\"msv-idx-ico\">&#x1f4c8;<\/div><span class=\"msv-idx-name\">Econometria \u00b7 Machine Learning \u00b7 Qualit\u00e0<\/span><span class=\"msv-idx-arr\">\u2192<\/span><\/a>\n      <\/div>\n    <\/div>\n  <\/section>\n\n  <!-- TARGET -->\n  <section class=\"msv-s2\">\n    <div class=\"msv-s2-wrap\">\n      <div class=\"msv-s2-head msv-reveal\">\n        <div class=\"msv-eyebrow\">Per chi lavoriamo<\/div>\n        <h2 class=\"msv-title xl\">Quattro target: <em>uno standard di qualit\u00e0.<\/em><\/h2>\n        <p>I nostri servizi scalano dalla tesi di dottorato al trial multicentrico, con la stessa metodologia e coerenza di linguaggio scientifico.<\/p>\n      <\/div>\n      <div class=\"msv-targets\">\n        <a class=\"msv-tgt msv-reveal\" href=\"https:\/\/www.mathsly.it\/wordpress\/servizi-per-ospedali-e-irccs\/\">\n          <div class=\"msv-tgt-ico\">&#x1f3e5;<\/div>\n          <div class=\"msv-tgt-name\">Ospedali, IRCCS e gruppi di ricerca clinica<\/div>\n          <div class=\"msv-tgt-desc\">Studi multicentrici, protocolli, systematic review e pubblicazioni peer-reviewed.<\/div>\n          <div class=\"msv-tgt-arr\">Scopri di pi\u00f9 \u2192<\/div>\n        <\/a>\n        <a class=\"msv-tgt msv-reveal d1\" href=\"https:\/\/www.mathsly.it\/wordpress\/supporto-aziende-farmaceutiche\/\">\n          <div class=\"msv-tgt-ico\">&#x1f3ed;<\/div>\n          <div class=\"msv-tgt-name\">Pharma, biotech e CRO<\/div>\n          <div class=\"msv-tgt-desc\">SAP, RWE, validazione modelli AI e submission regolatorie EMA\/FDA.<\/div>\n          <div class=\"msv-tgt-arr\">Scopri di pi\u00f9 \u2192<\/div>\n        <\/a>\n        <a class=\"msv-tgt msv-reveal d2\" href=\"https:\/\/www.mathsly.it\/wordpress\/servizi-per-universita\/\">\n          <div class=\"msv-tgt-ico\">&#x1f393;<\/div>\n          <div class=\"msv-tgt-name\">Universit\u00e0 e medici ricercatori<\/div>\n          <div class=\"msv-tgt-desc\">Tesi, dottorati, analisi dati, pubblicazioni e supporto metodologico.<\/div>\n          <div class=\"msv-tgt-arr\">Scopri di pi\u00f9 \u2192<\/div>\n        <\/a>\n        <a class=\"msv-tgt msv-reveal d3\" href=\"https:\/\/www.mathsly.it\/wordpress\/statistica-forense-medico-legale\/\">\n          <div class=\"msv-tgt-ico\">&#x2696;&#xfe0f;<\/div>\n          <div class=\"msv-tgt-name\">Periti medico-legali e avvocati<\/div>\n          <div class=\"msv-tgt-desc\">Perizie quantitative, nesso causale, perdita di chance e second opinion.<\/div>\n          <div class=\"msv-tgt-arr\">Scopri di pi\u00f9 \u2192<\/div>\n        <\/a>\n      <\/div>\n    <\/div>\n  <\/section>\n\n  <!-- GRIGLIA SERVIZI -->\n  <section class=\"msv-s3\">\n    <div class=\"msv-s3-wrap\">\n      <div class=\"msv-s3-header\">\n        <div class=\"msv-reveal\">\n          <div class=\"msv-eyebrow\">I nostri servizi<\/div>\n          <h2 class=\"msv-title xl\">Servizi progettati per essere <em>combinati tra loro.<\/em><\/h2>\n        <\/div>\n        <a href=\"https:\/\/www.mathsly.it\/wordpress\/contatti\/\" class=\"msv-btn solid msv-reveal d1\">Parliamo del tuo progetto<\/a>\n      <\/div>\n\n      <!-- \u2605 BLOCCO 1: Core consolidato -->\n      <div class=\"msv-block\">\n        <div class=\"msv-block-header\">\n          <h3>Core<\/h3>\n          <p>Servizi consolidati con track record documentato<\/p>\n        <\/div>\n        <div class=\"msv-grid\">\n\n          <article class=\"msv-card msv-reveal\" id=\"svc-clinica\">\n            <div class=\"msv-card-tag\">Biostatistica &amp; Clinical Research<\/div>\n            <div class=\"msv-card-title\">Studi Clinici e Biostatistica<\/div>\n            <p class=\"msv-card-desc\">Supporto completo alla progettazione, gestione e analisi di studi clinici \u2014 RCT, studi osservazionali e Real World Evidence (RWE). Deliverable ICH-GCP compliant e pronti per regulatory submission.<\/p>\n            <ul class=\"msv-card-list\">\n              <li>Disegno sperimentale, protocolli e randomizzazione<\/li>\n              <li>Descrittive, inferenza e modelli multivariati<\/li>\n              <li>Analisi di sopravvivenza (Kaplan\u2013Meier, Cox), dati longitudinali e mixed models<\/li>\n              <li>Statistical Analysis Plan (SAP) e Tables, Listings &amp; Figures (TLF)<\/li>\n            <\/ul>\n            <div class=\"msv-card-foot\">\n              <a class=\"msv-btn solid sm\" href=\"https:\/\/www.mathsly.it\/wordpress\/biostatistica-studi-clinici\/\">Scopri di pi\u00f9<\/a>\n              <a class=\"msv-btn outline sm\" href=\"https:\/\/www.mathsly.it\/wordpress\/contatti\/\">Richiedi info<\/a>\n            <\/div>\n          <\/article>\n\n          <article class=\"msv-card msv-reveal d1\" id=\"svc-meta\">\n            <div class=\"msv-card-tag\">Evidence Synthesis<\/div>\n            <div class=\"msv-card-title\">Systematic Review e Meta-analisi<\/div>\n            <p class=\"msv-card-desc\">Revisioni sistematiche e meta-analisi con reporting conforme a PRISMA 2020 e registrazione PROSPERO. Network meta-analysis (NMA) e valutazione GRADE.<\/p>\n            <ul class=\"msv-card-list\">\n              <li>PICO, strategia di ricerca bibliografica e selezione studi<\/li>\n              <li>Estrazione dati, rischio di bias (RoB 2, ROBINS-I) e sintesi<\/li>\n              <li>Forest plot, funnel plot, Egger test e sensitivity analysis<\/li>\n              <li>Network meta-analysis e indirect treatment comparison (ITC)<\/li>\n            <\/ul>\n            <div class=\"msv-card-foot\">\n              <a class=\"msv-btn solid sm\" href=\"https:\/\/www.mathsly.it\/wordpress\/revisioni-sistematiche-meta-analisi\/\">Scopri di pi\u00f9<\/a>\n              <a class=\"msv-btn outline sm\" href=\"https:\/\/www.mathsly.it\/wordpress\/contatti\/\">Richiedi info<\/a>\n            <\/div>\n          <\/article>\n\n          <article class=\"msv-card msv-reveal\" id=\"svc-writing\">\n            <div class=\"msv-card-tag\">Medical Writing<\/div>\n            <div class=\"msv-card-title\">Medical Writing e Proofreading<\/div>\n            <p class=\"msv-card-desc\">Stesura di articoli scientifici, report regolatori e documentazione EMA\/FDA. Conformit\u00e0 a CONSORT, STROBE, PRISMA e EQUATOR. Revisione avanzata in italiano e inglese.<\/p>\n            <ul class=\"msv-card-list\">\n              <li>Manoscritti per riviste internazionali peer-reviewed<\/li>\n              <li>Clinical Study Report (CSR) e documenti regolatori<\/li>\n              <li>Abstract, poster e presentazioni per conferenze scientifiche<\/li>\n              <li>Risposta ai revisori (response to reviewers) e resubmission<\/li>\n            <\/ul>\n            <div class=\"msv-card-foot\">\n              <a class=\"msv-btn solid sm\" href=\"https:\/\/www.mathsly.it\/wordpress\/medical-writing\/\">Scopri di pi\u00f9<\/a>\n              <a class=\"msv-btn outline sm\" href=\"https:\/\/www.mathsly.it\/wordpress\/contatti\/\">Richiedi info<\/a>\n            <\/div>\n          <\/article>\n\n          <article class=\"msv-card msv-reveal d1\" id=\"svc-protocolli\">\n            <div class=\"msv-card-tag\">Metodo &amp; SAP<\/div>\n            <div class=\"msv-card-title\">Protocolli di Ricerca e SAP<\/div>\n            <p class=\"msv-card-desc\">Redazione di protocolli di studio secondo standard internazionali e SAP con coerenza metodologica \u2014 per studi clinici, osservazionali e RWE.<\/p>\n            <ul class=\"msv-card-list\">\n              <li>Obiettivi primari e secondari, endpoint e ipotesi<\/li>\n              <li>Campionamento, power analysis e randomizzazione<\/li>\n              <li>SAP completo con pre-specified analysis e sensitivity analysis<\/li>\n              <li>Advisory indipendente pre-submission e audit metodologico<\/li>\n            <\/ul>\n            <div class=\"msv-card-foot\">\n              <a class=\"msv-btn solid sm\" href=\"https:\/\/www.mathsly.it\/wordpress\/biostatistica-studi-clinici\/\">Scopri di pi\u00f9<\/a>\n              <a class=\"msv-btn outline sm\" href=\"https:\/\/www.mathsly.it\/wordpress\/contatti\/\">Richiedi info<\/a>\n            <\/div>\n          <\/article>\n\n          <article class=\"msv-card msv-reveal\" id=\"svc-dispositivi\">\n            <div class=\"msv-card-tag\">Med-tech &amp; Regulatory<\/div>\n            <div class=\"msv-card-title\">Dispositivi Medici \u2014 MDR &amp; IVDR<\/div>\n            <p class=\"msv-card-desc\">Consulenza statistica per aziende med-tech e uffici Regulatory Affairs. Dalla pianificazione degli studi di performance alla documentazione tecnica per MDR, IVDR e FDA 510(k).<\/p>\n            <ul class=\"msv-card-list\">\n              <li>Accuratezza diagnostica, Gauge R&amp;R e capability di processo<\/li>\n              <li>Clinical Evaluation Report (CER) e PMCF per MDR\/IVDR<\/li>\n              <li>Protocolli CLSI per dispositivi IVD e studi di equivalenza<\/li>\n              <li>Piani statistici per 510(k) e studi di non-inferiorit\u00e0<\/li>\n            <\/ul>\n            <div class=\"msv-card-foot\">\n              <a class=\"msv-btn solid sm\" href=\"https:\/\/www.mathsly.it\/wordpress\/dispositivi-medici-validazione-statistica\/\">Scopri di pi\u00f9<\/a>\n              <a class=\"msv-btn outline sm\" href=\"https:\/\/www.mathsly.it\/wordpress\/contatti\/\">Richiedi info<\/a>\n            <\/div>\n          <\/article>\n\n          <article class=\"msv-card msv-reveal d1\" id=\"svc-dati\">\n            <div class=\"msv-card-tag\">Data Management<\/div>\n            <div class=\"msv-card-title\">Dati: Pulizia, Dataset e Questionari<\/div>\n            <p class=\"msv-card-desc\">Preparazione professionale dei dati per analisi affidabili e riproducibili. Progettazione di strumenti di raccolta per studi clinici e indagini epidemiologiche \u2014 incluso REDCap e eCRF.<\/p>\n            <ul class=\"msv-card-list\">\n              <li>Missing data, outlier detection, consistenza e standardizzazione<\/li>\n              <li>Database audit-ready per analisi e regulatory reporting<\/li>\n              <li>Progettazione questionari validati (Google Forms, REDCap, eCRF)<\/li>\n              <li>Verifica comprensibilit\u00e0, coerenza interna e validit\u00e0 di costrutto<\/li>\n            <\/ul>\n            <div class=\"msv-card-foot\">\n              <a class=\"msv-btn solid sm\" href=\"https:\/\/www.mathsly.it\/wordpress\/caricamento-dati-e-pulizia-dataset\/\">Scopri di pi\u00f9<\/a>\n              <a class=\"msv-btn outline sm\" href=\"https:\/\/www.mathsly.it\/wordpress\/contatti\/\">Richiedi info<\/a>\n            <\/div>\n          <\/article>\n\n        <\/div>\n      <\/div>\n\n      <!-- \u2605 BLOCCO 2: Mercato da sviluppare -->\n      <div class=\"msv-block\">\n        <div class=\"msv-block-header\">\n          <h3>Also Specialized<\/h3>\n          <p>Competenze rare, metodo rigoroso<\/p>\n        <\/div>\n        <div class=\"msv-grid\">\n\n          <article class=\"msv-card sviluppo msv-reveal\" id=\"svc-advisory\">\n            <div class=\"msv-card-tag\">Advisory Indipendente \u00b7 IDMC<\/div>\n            <div class=\"msv-card-title\">Advisory Metodologico Indipendente<\/div>\n            <p class=\"msv-card-desc\">Valutazione critica esterna su studi, analisi e protocolli \u2014 senza conflitti di interesse. Audit metodologico, second opinion, partecipazione come statistico in IDMC\/DSMB. Report scritto, firmato e difendibile in contesti regolatori, editoriali e legali.<\/p>\n            <ul class=\"msv-card-list\">\n              <li>Audit metodologico e second opinion pre-submission<\/li>\n              <li>Statistico indipendente in IDMC\/DSMB per trial in corso<\/li>\n              <li>SAP per analisi ad interim e DMC Charter<\/li>\n              <li>Valutazione critica di revisioni sistematiche (AMSTAR2)<\/li>\n            <\/ul>\n            <div class=\"msv-card-foot\">\n              <a class=\"msv-btn solid sm\" href=\"https:\/\/www.mathsly.it\/wordpress\/advisory-metodologico-indipendente\/\">Scopri di pi\u00f9<\/a>\n              <a class=\"msv-btn outline sm\" href=\"https:\/\/www.mathsly.it\/wordpress\/contatti\/\">Richiedi info<\/a>\n            <\/div>\n          <\/article>\n\n          <article class=\"msv-card sviluppo msv-reveal d1\" id=\"svc-ai\">\n            <div class=\"msv-card-tag\">AI Validation &amp; Regulatory<\/div>\n            <div class=\"msv-card-title\">Validazione Statistica Modelli AI<\/div>\n            <p class=\"msv-card-desc\">Validazione statistica indipendente di modelli predittivi AI\/ML per la ricerca clinica e farmaceutica. Audit, analisi di fairness, conformit\u00e0 EMA\/FDA e report formali allegabili a dossier regolatori.<\/p>\n            <ul class=\"msv-card-list\">\n              <li>Audit statistico: AUC, calibrazione, data leakage, validazione esterna<\/li>\n              <li>Fairness e sottogruppi: bias algoritmico, demographic parity<\/li>\n              <li>Conformit\u00e0 TRIPOD+AI, FDA guidance e EU AI Act (healthcare)<\/li>\n              <li>Report per submission EMA\/FDA, pubblicazione e due diligence<\/li>\n            <\/ul>\n            <div class=\"msv-card-foot\">\n              <a class=\"msv-btn solid sm\" href=\"https:\/\/www.mathsly.it\/wordpress\/validazione-modelli-ai-pharma\/\">Scopri di pi\u00f9<\/a>\n              <a class=\"msv-btn outline sm\" href=\"https:\/\/www.mathsly.it\/wordpress\/contatti\/\">Richiedi info<\/a>\n            <\/div>\n          <\/article>\n\n          <article class=\"msv-card sviluppo msv-reveal\" id=\"svc-forense\">\n            <div class=\"msv-card-tag\">Statistica Forense &amp; Medico-Legale<\/div>\n            <div class=\"msv-card-title\">Statistica Forense e Medico-Legale<\/div>\n            <p class=\"msv-card-desc\">Supporto quantitativo in ambito medico-legale e giudiziario per la valutazione di nesso causale, perdita di chance, rischio clinico e quantificazione del danno. Approccio evidence-based con metodologia esplicita e difendibile.<\/p>\n            <ul class=\"msv-card-list\">\n              <li>Analisi probabilistica del nesso causale e causalit\u00e0 controfattuale<\/li>\n              <li>Perdita di chance e loss of opportunity analysis<\/li>\n              <li>Modelli di rischio, analisi di sopravvivenza e danno futuro<\/li>\n              <li>Validazione di stime liquidative e second opinion su perizie<\/li>\n            <\/ul>\n            <div class=\"msv-card-foot\">\n              <a class=\"msv-btn solid sm\" href=\"https:\/\/www.mathsly.it\/wordpress\/statistica-forense-medico-legale\/\">Scopri di pi\u00f9<\/a>\n              <a class=\"msv-btn outline sm\" href=\"https:\/\/www.mathsly.it\/wordpress\/contatti\/\">Richiedi info<\/a>\n            <\/div>\n          <\/article>\n\n        <\/div>\n      <\/div>\n\n      <!-- \u2605 BLOCCO 3: Periferia \u2014 card compatte -->\n      <div class=\"msv-block\" id=\"svc-altro\">\n        <div class=\"msv-block-header\">\n          <h3>Extended Services<\/h3>\n          <p>Statistica applicata in altri settori<\/p>\n        <\/div>\n        <div class=\"msv-grid compact\">\n\n          <article class=\"msv-card compact msv-reveal\" id=\"svc-econometria\">\n            <div class=\"msv-card-tag\">Econometria<\/div>\n            <div class=\"msv-card-title\">Econometria e Scienze Sociali<\/div>\n            <p class=\"msv-card-desc\">Regressioni OLS\/IV, modelli panel, DiD, PSM, serie storiche e policy evaluation e molto altro.<\/p>\n            <div class=\"msv-card-foot\">\n              <a class=\"msv-btn outline sm\" href=\"https:\/\/www.mathsly.it\/wordpress\/econometria\/\">Scopri di pi\u00f9<\/a>\n            <\/div>\n          <\/article>\n\n          <article class=\"msv-card compact msv-reveal d1\" id=\"svc-ml\">\n            <div class=\"msv-card-tag\">Machine Learning<\/div>\n            <div class=\"msv-card-title\">Machine Learning e Big Data<\/div>\n            <p class=\"msv-card-desc\">Modelli predittivi TRIPOD-compliant, deep learning, NLP e explainable AI per ricerca scientifica.<\/p>\n            <div class=\"msv-card-foot\">\n              <a class=\"msv-btn outline sm\" href=\"https:\/\/www.mathsly.it\/wordpress\/machine-learning\/\">Scopri di pi\u00f9<\/a>\n            <\/div>\n          <\/article>\n\n          <article class=\"msv-card compact msv-reveal d2\" id=\"svc-qualita\">\n            <div class=\"msv-card-tag\">Statistica Industriale<\/div>\n            <div class=\"msv-card-title\">Controllo Qualit\u00e0 e SPC<\/div>\n            <p class=\"msv-card-desc\">SPC, Gauge R&amp;R, capability Cp\/Cpk, DOE e piani di campionamento per qualit\u00e0 industriale e farmaceutica.<\/p>\n            <div class=\"msv-card-foot\">\n              <a class=\"msv-btn outline sm\" href=\"https:\/\/www.mathsly.it\/wordpress\/statistica-industriale-controllo-qualita\/\">Scopri di pi\u00f9<\/a>\n            <\/div>\n          <\/article>\n\n        <\/div>\n      <\/div>\n\n    <\/div>\n  <\/section>\n\n  <!-- DIFFERENZIATORI -->\n  <section class=\"msv-s4\">\n    <div class=\"msv-s4-wrap\">\n      <div class=\"msv-s4-head msv-reveal\">\n        <div class=\"msv-eyebrow\">Perch\u00e9 Mathsly Research<\/div>\n        <h2 class=\"msv-title xl\">Quattro motivi per <em>sceglierci.<\/em><\/h2>\n        <p>Non siamo una CRO generalista n\u00e9 un freelance improvvisato. Siamo una struttura di consulenza scientifica con una direzione accademica riconosciuta e un posizionamento metodologico indipendente.<\/p>\n      <\/div>\n      <div class=\"msv-diffs\">\n        <div class=\"msv-diff msv-reveal\">\n          <div class=\"msv-diff-n\">01 \u2014 Autorit\u00e0 scientifica<\/div>\n          <div class=\"msv-diff-title\">Direzione accademica riconosciuta<\/div>\n          <div class=\"msv-diff-desc\">Mathsly Research \u00e8 guidata dalla <strong>Prof.ssa Maril\u00f9 Garo<\/strong>, 90+ pubblicazioni peer-reviewed e revisore per Frontiers, MDPI, Elsevier, Wiley e Springer Nature. 12+ anni di consulenza su studi clinici, pubblicazioni e dossier regolatori.<\/div>\n        <\/div>\n        <div class=\"msv-diff msv-reveal d1\">\n          <div class=\"msv-diff-n\">02 \u2014 Indipendenza metodologica<\/div>\n          <div class=\"msv-diff-title\">Advisory senza conflitti di interesse<\/div>\n          <div class=\"msv-diff-desc\">Lavoriamo con pharma e CRO come clienti diretti, <strong>senza vincoli esclusivi n\u00e9 legami strutturali con sponsor<\/strong>. La scelta ideale per second opinion pre-submission, audit indipendenti e due diligence per investitori biotech.<\/div>\n        <\/div>\n        <div class=\"msv-diff msv-reveal\">\n          <div class=\"msv-diff-n\">03 \u2014 Capacit\u00e0 di urgenza<\/div>\n          <div class=\"msv-diff-title\">Turnaround accelerato per deadline strette<\/div>\n          <div class=\"msv-diff-desc\">Per submission EMA\/FDA, risposta a revisori e presentazioni a congressi: <strong>SAP in 3\u20137 giorni<\/strong> (standard 7\u201314), <strong>audit metodologico in 3\u20135 giorni<\/strong> (standard 5\u201310). Primo feedback sempre entro 24 ore.<\/div>\n        <\/div>\n        <div class=\"msv-diff msv-reveal d1\">\n          <div class=\"msv-diff-n\">04 \u2014 Approccio end-to-end<\/div>\n          <div class=\"msv-diff-title\">Un referente unico, dalla progettazione alla pubblicazione<\/div>\n          <div class=\"msv-diff-desc\">Non dovrai coordinare tre fornitori diversi \u2014 <strong>biostatistico, medical writer, metodologo<\/strong>. Un unico interlocutore scientifico per protocollo, SAP, analisi, medical writing e submission. Coerenza metodologica garantita.<\/div>\n        <\/div>\n      <\/div>\n    <\/div>\n  <\/section>\n\n  <!-- GARANZIA DI PROCESSO -->\n  <section class=\"msv-s4b\">\n    <div class=\"msv-s4b-wrap\">\n      <div class=\"msv-s4b-head msv-reveal\">\n        <div class=\"msv-eyebrow light\">Garanzia di processo<\/div>\n        <h2 class=\"msv-title xl\">Cosa \u00e8 incluso in <em>ogni progetto.<\/em><\/h2>\n        <p>Non \u00e8 una policy, \u00e8 come lavoriamo. Tre garanzie di metodo che si applicano a ogni nostro incarico, indipendentemente dal servizio richiesto.<\/p>\n      <\/div>\n      <div class=\"msv-guar\">\n\n        <div class=\"msv-guar-card msv-reveal\">\n          <div class=\"msv-guar-num\">01 \u2014 Pre-specificazione<\/div>\n          <div class=\"msv-guar-icon\">&#x1f4cb;<\/div>\n          <div class=\"msv-guar-title\">SAP prima dei dati<\/div>\n          <div class=\"msv-guar-desc\">Il piano di analisi statistica viene <strong>redatto e firmato prima di vedere i dati<\/strong>. Questo elimina il rischio di analisi post-hoc e rende ogni scelta metodologica trasparente, tracciabile e difendibile in sede regolatoria o editoriale.<\/div>\n          <span class=\"msv-guar-tag\">ICH E9(R1) compliant<\/span>\n        <\/div>\n\n        <div class=\"msv-guar-card msv-reveal d1\">\n          <div class=\"msv-guar-num\">02 \u2014 Output firmati<\/div>\n          <div class=\"msv-guar-icon\">&#x270d;&#xfe0f;<\/div>\n          <div class=\"msv-guar-title\">Ogni deliverable \u00e8 firmato<\/div>\n          <div class=\"msv-guar-desc\">Tutti i report, SAP e output metodologici vengono <strong>consegnati con firma della Direttrice Scientifica<\/strong>. La paternit\u00e0 \u00e8 esplicita: il documento \u00e8 presentabile in dossier regolatori, contesti legali, audit di qualit\u00e0 e peer-review.<\/div>\n          <span class=\"msv-guar-tag\">Audit-ready<\/span>\n        <\/div>\n\n        <div class=\"msv-guar-card msv-reveal d2\">\n          <div class=\"msv-guar-num\">03 \u2014 Assistenza in review<\/div>\n          <div class=\"msv-guar-icon\">&#x1f6e1;&#xfe0f;<\/div>\n          <div class=\"msv-guar-title\">Review coverage su ogni lavoro<\/div>\n          <div class=\"msv-guar-desc\">Ogni nostro progetto include <strong>assistenza nella fase di risposta ai revisori<\/strong>. Se il manoscritto o il dossier riceve commenti metodologici, siamo disponibili per supportare la replica \u2014 senza avviare un nuovo incarico da zero.<\/div>\n          <span class=\"msv-guar-tag\">Incluso in ogni progetto<\/span>\n        <\/div>\n\n      <\/div>\n    <\/div>\n  <\/section>\n\n  <!-- TEMPI E PREZZI -->\n  <section class=\"msv-s5\">\n    <div class=\"msv-s5-wrap\">\n      <div class=\"msv-s5-head msv-reveal\">\n        <div class=\"msv-eyebrow\">Tempi e investimento<\/div>\n        <h2 class=\"msv-title xl\">Trasparenza su <em>tempi e costi.<\/em><\/h2>\n        <p>I deliverable principali, con i tempi tipici di consegna e gli ordini di grandezza dell&#8217;investimento. Il preventivo definitivo si dimensiona dopo l&#8217;inquadramento del progetto.<\/p>\n      <\/div>\n      <div class=\"msv-split\">\n        <div class=\"msv-panel msv-reveal\">\n          <div class=\"msv-panel-label\">Tempi indicativi<\/div>\n          <div class=\"msv-panel-title\">Deliverable pi\u00f9 richiesti<\/div>\n          <div class=\"msv-timesrow\"><div><div class=\"msv-times-n\">Primo feedback dopo il contatto<\/div><div class=\"msv-times-std\"><strong>Entro 24 ore<\/strong><\/div><\/div><\/div>\n          <div class=\"msv-timesrow\"><div><div class=\"msv-times-n\">Statistical Analysis Plan (SAP)<\/div><div class=\"msv-times-std\"><strong>7\u201314 giorni<\/strong> standard<\/div><div class=\"msv-times-urg\"><strong>3\u20137 giorni<\/strong> in urgenza<\/div><\/div><\/div>\n          <div class=\"msv-timesrow\"><div><div class=\"msv-times-n\">Audit metodologico \/ second opinion<\/div><div class=\"msv-times-std\"><strong>5\u201310 giorni<\/strong> standard<\/div><div class=\"msv-times-urg\"><strong>3\u20135 giorni<\/strong> in urgenza<\/div><\/div><\/div>\n          <div class=\"msv-timesrow\"><div><div class=\"msv-times-n\">Systematic review con meta-analisi<\/div><div class=\"msv-times-std\"><strong>1\u20132 mesi<\/strong> standard<\/div><div class=\"msv-times-urg\"><strong>2\u20134 settimane<\/strong> in urgenza<\/div><\/div><\/div>\n        <\/div>\n        <div class=\"msv-panel msv-reveal d1\">\n          <div class=\"msv-panel-label\">Investimento tipico<\/div>\n          <div class=\"msv-panel-title\">Punti di partenza<\/div>\n          <div class=\"msv-pricerow\"><div class=\"msv-price-name\">Statistical Analysis Plan (SAP)<\/div><div class=\"msv-price-val\"><small>da<\/small>2.800\u20ac<\/div><\/div>\n          <div class=\"msv-pricerow\"><div class=\"msv-price-name\">Audit metodologico \/ second opinion<\/div><div class=\"msv-price-val\"><small>da<\/small>1.500\u20ac<\/div><\/div>\n          <div class=\"msv-pricerow\"><div class=\"msv-price-name\">Systematic review con meta-analisi<\/div><div class=\"msv-price-val\"><small>da<\/small>5.000\u20ac<\/div><\/div>\n          <div class=\"msv-pricerow\"><div class=\"msv-price-name\">Consulenza biostatistica per pubblicazione<\/div><div class=\"msv-price-val\"><small>da<\/small>1.500\u20ac<\/div><\/div>\n          <div class=\"msv-pricerow\"><div class=\"msv-price-name\">Medical writing (articolo scientifico)<\/div><div class=\"msv-price-val\"><small>da<\/small>3.200\u20ac<\/div><\/div>\n          <div class=\"msv-price-frame\"><strong>Ogni progetto \u00e8 diverso.<\/strong> Questi sono i punti di partenza \u2014 il preventivo finale riflette la complessit\u00e0 dello studio e i deliverable richiesti. Rispondiamo entro 24 ore.<\/div>\n        <\/div>\n      <\/div>\n    <\/div>\n  <\/section>\n\n  <!-- FAQ -->\n  <section class=\"msv-s6\">\n    <div class=\"msv-s6-wrap\">\n      <div class=\"msv-s6-head msv-reveal\">\n        <div class=\"msv-eyebrow light\">Domande frequenti<\/div>\n        <h2 class=\"msv-title xl\">Le risposte che <em>ci chiedono pi\u00f9 spesso.<\/em><\/h2>\n        <p>Tempi, modalit\u00e0 di collaborazione, indipendenza e standard metodologici \u2014 tutto quello che serve sapere prima di contattarci.<\/p>\n      <\/div>\n      <details class=\"msv-faq msv-reveal\">\n        <summary>Come funziona la prima fase di contatto? <span class=\"msv-faq-icon\">+<\/span><\/summary>\n        <div class=\"msv-faq-body\">Rispondiamo entro 24 ore a ogni richiesta con un&#8217;analisi di fattibilit\u00e0 senza impegno. Raccogliamo documentazione, chiariamo obiettivi e vincoli, e solo allora emettiamo una proposta metodologica dimensionata con precisione. <strong>Evitiamo volutamente stime &#8220;a occhio&#8221;<\/strong> per garantire tempi e costi difendibili.<\/div>\n      <\/details>\n      <details class=\"msv-faq msv-reveal\">\n        <summary>Lavorate anche in urgenza? <span class=\"msv-faq-icon\">+<\/span><\/summary>\n        <div class=\"msv-faq-body\">S\u00ec. Per deadline strette \u2014 submission regolatorie, risposta a revisori, presentazioni a congressi \u2014 acceleriamo i tempi: <strong>SAP in 3\u20137 giorni<\/strong> (standard 7\u201314), <strong>audit in 3\u20135 giorni<\/strong> (standard 5\u201310).<\/div>\n      <\/details>\n      <details class=\"msv-faq msv-reveal\">\n        <summary>Come funziona la collaborazione? Avr\u00f2 un referente unico? <span class=\"msv-faq-icon\">+<\/span><\/summary>\n        <div class=\"msv-faq-body\">S\u00ec, Mathsly Research \u00e8 organizzata per garantire <strong>un referente scientifico unico<\/strong> per tutto il progetto. Non coordinerai tre fornitori separati (biostatistico, medical writer, metodologo): tutto passa da un&#8217;unica interfaccia.<\/div>\n      <\/details>\n      <details class=\"msv-faq msv-reveal\">\n        <summary>Siete indipendenti? Firmate accordi di riservatezza? <span class=\"msv-faq-icon\">+<\/span><\/summary>\n        <div class=\"msv-faq-body\">S\u00ec a entrambe. Mathsly Research \u00e8 una struttura indipendente: <strong>lavoriamo con CRO e aziende pharma come clienti diretti, senza vincoli esclusivi n\u00e9 legami strutturali con sponsor<\/strong>. Firmiamo NDA prima di ricevere dati o protocolli, e accettiamo i vostri template contrattuali (MSA, SoW).<\/div>\n      <\/details>\n      <details class=\"msv-faq msv-reveal\">\n        <summary>Quali linee guida seguite nei deliverable? <span class=\"msv-faq-icon\">+<\/span><\/summary>\n        <div class=\"msv-faq-body\">Lavoriamo conformi a <strong>ICH-GCP<\/strong> per clinical trial, <strong>CONSORT<\/strong> per RCT, <strong>STROBE<\/strong> per osservazionali, <strong>PRISMA 2020<\/strong> per systematic review, <strong>TRIPOD<\/strong> per modelli predittivi, <strong>GRADE<\/strong> per evidence synthesis. I deliverable sono audit-ready per EMA, FDA e peer-review.<\/div>\n      <\/details>\n    <\/div>\n  <\/section>\n\n  <!-- CTA -->\n  <section class=\"msv-s7\" style=\"position:relative;\">\n    <div class=\"msv-s7-bar\"><\/div>\n    <div class=\"msv-s7-wrap\">\n      <div class=\"msv-s7-left msv-reveal\">\n        <div class=\"msv-eyebrow\">Parliamo del tuo progetto<\/div>\n        <h2 class=\"msv-title lg\">Hai bisogno di supporto per la tua <em>ricerca?<\/em><\/h2>\n        <p>Inviaci una breve descrizione dell&#8217;obiettivo, del tipo di studio e dei dati disponibili. Valutiamo rapidamente e definiamo i deliverable pi\u00f9 adatti al tuo contesto.<\/p>\n        <div class=\"msv-s7-btns\">\n          <a class=\"msv-btn solid\" href=\"https:\/\/www.mathsly.it\/wordpress\/contatti\/\">Parliamo del tuo progetto<\/a>\n          <a class=\"msv-btn outline\" href=\"https:\/\/www.mathsly.it\/wordpress\/prenotazione-appuntamento\/\">Prenota una call<\/a>\n        <\/div>\n      <\/div>\n      <div class=\"msv-s7-right msv-reveal d1\">\n        <div class=\"msv-feat\"><div class=\"msv-feat-title\">End-to-end<\/div><div class=\"msv-feat-desc\">Dal disegno dello studio al reporting finale ICH-compliant<\/div><\/div>\n        <div class=\"msv-feat\"><div class=\"msv-feat-title\">Difendibili<\/div><div class=\"msv-feat-desc\">Metodologia esplicita, tracciabile e riproducibile<\/div><\/div>\n        <div class=\"msv-feat\"><div class=\"msv-feat-title\">Risposta rapida<\/div><div class=\"msv-feat-desc\">Feedback entro 24 ore, preventivo dopo inquadramento<\/div><\/div>\n        <div class=\"msv-feat\"><div class=\"msv-feat-title\">100% online<\/div><div class=\"msv-feat-desc\">Consulenza ovunque tu sia, senza vincoli geografici<\/div><\/div>\n      <\/div>\n    <\/div>\n  <\/section>\n\n<\/div>\n\n<script>\n(function(){\n  var io = new IntersectionObserver(function(entries){\n    entries.forEach(function(e){\n      if(e.isIntersecting){ e.target.classList.add(\"up\"); io.unobserve(e.target); }\n    });\n  }, { threshold: 0.07 });\n  document.querySelectorAll(\".msv-reveal:not(.msv-lcp)\").forEach(function(el){ io.observe(el); });\n})();\n<\/script>\n","protected":false},"excerpt":{"rendered":"<p>Mathsly Research offre consulenza statistica e biostatistica indipendente per ricerca clinica, pharma, CRO, IRCCS e accademia. Fondata da Maril\u00f9 Garo (matematico, 90+ pubblicazioni peer-reviewed, H-index 14 Scopus). Primo feedback entro 24 ore. Email: info@mathsly.it. Servizi: biostatistica per studi clinici (SAP ICH E9\/E9(R1), RCT, RWE, TLF per CSR), revisioni sistematiche e meta-analisi (PRISMA 2020, GRADE, NMA, &#8230; <a title=\"Servizi\" class=\"read-more\" href=\"https:\/\/www.mathsly.it\/wordpress\/servizi\/\" aria-label=\"Per saperne di pi\u00f9 su Servizi\">Leggi tutto<\/a><\/p>\n","protected":false},"author":138,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-18383","page","type-page","status-publish"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.7 (Yoast SEO v28.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Servizi Biostatistica e Metodologia della Ricerca - Mathsly Research<\/title>\n<meta name=\"description\" content=\"Biostatistica, SAP, revisioni sistematiche e medical writing. 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