{"id":24599,"date":"2026-04-20T10:41:18","date_gmt":"2026-04-20T08:41:18","guid":{"rendered":"https:\/\/www.mathsly.it\/wordpress\/?page_id=24599"},"modified":"2026-07-23T11:42:52","modified_gmt":"2026-07-23T09:42:52","slug":"mathsly-design","status":"publish","type":"page","link":"https:\/\/www.mathsly.it\/wordpress\/mathsly-design\/","title":{"rendered":"Mathsly Design"},"content":{"rendered":"\n<!-- ============================================================\n  MATHSLY RESEARCH \u2014 Pagina Mathsly Design\n  Aggiornamento giugno 2026: Fraunces, design arioso\n  SEO: geo capsule intatta, H1\/H2 keyword, link interni preservati\n============================================================ -->\n\n<link rel=\"preconnect\" href=\"https:\/\/fonts.googleapis.com\">\n<link rel=\"preconnect\" href=\"https:\/\/fonts.gstatic.com\" crossorigin=\"\">\n<link href=\"https:\/\/fonts.googleapis.com\/css2?family=Fraunces:ital,opsz,wght@0,9..144,400;0,9..144,600;0,9..144,700;1,9..144,400;1,9..144,600;1,9..144,700&amp;family=DM+Sans:wght@300;400;500;600&amp;display=swap\" rel=\"stylesheet\">\n\n<style>\n.mds *, .mds *::before, .mds *::after { box-sizing: border-box; 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}\n.mds-s7-bar { position: absolute; top: 0; left: 0; right: 0; height: 3px; background: linear-gradient(90deg, var(--teal), var(--gold), var(--teal)); }\n.mds-s7-wrap { max-width: 680px; margin: 0 auto; padding: 88px 8vw; text-align: center; position: relative; }\n.mds-s7-wrap .mds-title.lg { color: var(--white); margin: 12px 0 16px; }\n.mds-s7-wrap .mds-title.lg em { font-style: italic; color: var(--teal-lt); }\n.mds-s7-wrap p { font-size: 16px; line-height: 1.8; color: rgba(255,255,255,.50); margin-bottom: 28px; }\n.mds-s7-btns { display: flex; flex-wrap: wrap; gap: 10px; justify-content: center; }\n\n@media (max-width: 1024px) {\n  .mds-s1-wrap, .mds-s2-wrap, .mds-s4-wrap, .mds-s5-wrap { grid-template-columns: 1fr; gap: 48px; }\n  .mds-s1-wrap { padding-top: 72px; }\n  .mds-items { grid-template-columns: 1fr 1fr; }\n  .mds-lines { grid-template-columns: 1fr; }\n}\n@media (max-width: 768px) {\n  .mds-s1-wrap, .mds-s2-wrap, .mds-s3-wrap, .mds-s4-wrap, .mds-s5-wrap, .mds-s6-wrap, .mds-s7-wrap { padding: 64px 5vw; }\n  .mds-items { grid-template-columns: 1fr; }\n  .mds-hero-card-two { grid-template-columns: 1fr; }\n}\n<\/style>\n\n<div class=\"mds\">\n\n  <div style=\"position:relative;\">\n    <p class=\"mds-geo\">Mathsly Design \u00e8 il servizio di Mathsly Research dedicato alla progettazione statistica di studi clinici e di ricerca. Deliverable: definizione endpoint ed estimand ICH E9(R1), scelta disegno (RCT, osservazionale, RWE, crossover, adattivo), calcolo sample size per submission EMA\/FDA, redazione protocollo (CONSORT, STROBE, PRISMA, ICH E6), Statistical Analysis Plan (SAP) pre-specificato con missing data, sensitivity analysis e TLF shells, advisory metodologico indipendente. Si rivolge a: ricercatori clinici, pharma, biotech, IRCCS, CRO. Prima delle tre linee Mathsly: Design, Analysis, Review. Preventivo gratuito entro 24 ore.<\/p>\n  <\/div>\n\n  <!-- HERO -->\n  <section class=\"mds-s1\">\n    <div class=\"mds-s1-bar\"><\/div>\n    <div class=\"mds-glow a\"><\/div>\n    <div class=\"mds-glow b\"><\/div>\n    <div class=\"mds-s1-wrap\">\n      <div>\n        <div class=\"mds-s1-badge\">\u2460 Design<\/div>\n        <h1 class=\"mds-title hero mds-s1-title mds-lcp\">Mathsly <em>Design<\/em><\/h1>\n        <p class=\"mds-s1-claim mds-lcp\">Progettiamo lo studio prima che i dati esistano.<\/p>\n        <p class=\"mds-s1-sub mds-lcp\">Il momento in cui uno studio clinico pu\u00f2 essere salvato \u2014 o compromesso \u2014 \u00e8 prima che il primo paziente venga arruolato. Noi lavoriamo in quella fase.<\/p>\n        <div class=\"mds-s1-btns mds-reveal\">\n          <a class=\"mds-btn solid\" href=\"https:\/\/www.mathsly.it\/wordpress\/contatti\/\">Parliamo del tuo studio<\/a>\n          <a class=\"mds-btn outline-light\" href=\"https:\/\/www.mathsly.it\/wordpress\/servizi\/\">Tutti i servizi \u2192<\/a>\n        <\/div>\n      <\/div>\n      <div class=\"mds-s1-right mds-reveal d1\">\n        <div class=\"mds-hero-card-two\">\n          <div class=\"mds-hero-card accent\">\n            <div class=\"mds-hero-card-label\">Risposta<\/div>\n            <div class=\"mds-hero-card-val\" style=\"font-family:'Fraunces',serif;font-size:26px;font-weight:700;color:#fff;letter-spacing:-.02em;\">24h<\/div>\n            <div style=\"font-size:11px;color:rgba(255,255,255,.35);margin-top:3px;\">Preventivo gratuito<\/div>\n          <\/div>\n          <div class=\"mds-hero-card\">\n            <div class=\"mds-hero-card-label\">Standard<\/div>\n            <div class=\"mds-hero-card-val\">ICH E9(R1) \u00b7 EMA \u00b7 FDA<\/div>\n            <div style=\"font-size:11px;color:rgba(255,255,255,.35);margin-top:3px;\">SAP pre-specificato<\/div>\n          <\/div>\n        <\/div>\n        <div class=\"mds-hero-card\">\n          <div class=\"mds-hero-card-label\">Deliverable principali<\/div>\n          <div class=\"mds-hero-card-val\">Endpoint \u00b7 Sample size \u00b7 Protocollo \u00b7 SAP \u00b7 Advisory indipendente<\/div>\n        <\/div>\n        <div class=\"mds-hero-card accent\">\n          <div class=\"mds-hero-card-label\">Il principio<\/div>\n          <div class=\"mds-hero-card-val italic\">&#8220;La tua ricerca merita un&#8217;analisi all&#8217;altezza. E un&#8217;analisi all&#8217;altezza inizia dal disegno.&#8221;<\/div>\n        <\/div>\n      <\/div>\n    <\/div>\n  <\/section>\n\n  <!-- PROBLEMA -->\n  <section class=\"mds-s2\">\n    <div class=\"mds-s2-wrap\">\n      <div class=\"mds-s2-left mds-reveal\">\n        <div class=\"mds-eyebrow\">Il problema che vediamo spesso<\/div>\n        <h2 class=\"mds-title lg\">Molti studi falliscono <em>prima dell&#8217;analisi.<\/em><\/h2>\n        <p>Molti studi arrivano all&#8217;analisi con problemi che non nascono dai dati: nascono dal disegno. Un endpoint mal definito. Un campione sottodimensionato. Un protocollo che non chiarisce come gestire i dropout. Un SAP scritto dopo aver visto i risultati.<\/p>\n        <p><strong>Nessuno di questi problemi \u00e8 recuperabile a posteriori. Tutti sono evitabili \u2014 se affrontati prima.<\/strong><\/p>\n      <\/div>\n      <div class=\"mds-s2-right mds-reveal d1\">\n        <div class=\"mds-s2-right-label\">Il principio che guida il nostro lavoro<\/div>\n        <div class=\"mds-quote\">&#8220;La tua ricerca merita un&#8217;analisi all&#8217;altezza. E un&#8217;analisi all&#8217;altezza inizia dal disegno.&#8221;<\/div>\n      <\/div>\n    <\/div>\n  <\/section>\n\n  <!-- COSA FACCIAMO -->\n  <section class=\"mds-s3\">\n    <div class=\"mds-s3-wrap\">\n      <div class=\"mds-s3-head mds-reveal\">\n        <div class=\"mds-eyebrow\">Su cosa lavoriamo con te<\/div>\n        <h2 class=\"mds-title lg\">Dalla domanda di ricerca al <em>protocollo pronto.<\/em><\/h2>\n        <p>Ogni deliverable \u00e8 pre-specificato, documentato e difendibile davanti a un comitato etico, un ente regolatorio o un reviewer di rivista internazionale.<\/p>\n      <\/div>\n      <div class=\"mds-items\">\n        <div class=\"mds-item mds-reveal\">\n          <div class=\"mds-item-n\">01<\/div>\n          <div class=\"mds-item-title\">Obiettivi ed endpoint<\/div>\n          <div class=\"mds-item-desc\">Definizione degli endpoint primari e secondari, delle ipotesi di ricerca e degli estimand secondo ICH E9(R1). Senza ambiguit\u00e0 interpretative.<\/div>\n        <\/div>\n        <div class=\"mds-item mds-reveal d1\">\n          <div class=\"mds-item-n\">02<\/div>\n          <div class=\"mds-item-title\">Disegno dello studio<\/div>\n          <div class=\"mds-item-desc\">Scelta e giustificazione del disegno (RCT, osservazionale, RWE, crossover, adaptive) in funzione della domanda di ricerca e dei vincoli operativi.<\/div>\n        <\/div>\n        <div class=\"mds-item mds-reveal d2\">\n          <div class=\"mds-item-n\">03<\/div>\n          <div class=\"mds-item-title\">Sample size<\/div>\n          <div class=\"mds-item-desc\">Calcolo della dimensione campionaria con assunzioni esplicitate e difendibili: effect size, variabilit\u00e0, potenza, livello di significativit\u00e0, correzioni per confronti multipli.<\/div>\n        <\/div>\n        <div class=\"mds-item mds-reveal\">\n          <div class=\"mds-item-n\">04<\/div>\n          <div class=\"mds-item-title\">Protocollo di ricerca<\/div>\n          <div class=\"mds-item-desc\">Redazione del protocollo secondo gli standard CONSORT, STROBE, PRISMA o ICH E6 pertinenti allo studio. Pronto per submission al comitato etico.<\/div>\n        <\/div>\n        <div class=\"mds-item mds-reveal d1\">\n          <div class=\"mds-item-n\">05<\/div>\n          <div class=\"mds-item-title\">Statistical Analysis Plan<\/div>\n          <div class=\"mds-item-desc\">SAP pre-specificato con popolazioni analitiche, metodi statistici, gestione dei missing data, sensitivity analysis e TLF shells. Redatto prima del database lock.<\/div>\n        <\/div>\n        <div class=\"mds-item mds-reveal d2\">\n          <div class=\"mds-item-n\">06<\/div>\n          <div class=\"mds-item-title\">Advisory indipendente<\/div>\n          <div class=\"mds-item-desc\">Revisione metodologica di protocolli gi\u00e0 esistenti che non convincono. Second opinion prima della submission al comitato etico o all&#8217;ente regolatorio.<\/div>\n        <\/div>\n      <\/div>\n    <\/div>\n  <\/section>\n\n  <!-- PER CHI -->\n  <section class=\"mds-s4\">\n    <div class=\"mds-s4-wrap\">\n      <div class=\"mds-s4-left mds-reveal\">\n        <div class=\"mds-eyebrow light\">Per chi \u00e8 pensato<\/div>\n        <h2 class=\"mds-title lg\">Chi \u00e8 all&#8217;inizio o ha un protocollo che <em>non convince.<\/em><\/h2>\n        <p>Mathsly Design \u00e8 il punto di ingresso naturale per chi sta progettando uno studio \u2014 o ha gi\u00e0 un protocollo che vuole rafforzare prima della submission.<\/p>\n        <p>Lavoriamo con te dall&#8217;inizio, o entriamo nel progetto in qualsiasi fase in cui la progettazione ha ancora bisogno di un supporto metodologico solido.<\/p>\n      <\/div>\n      <div class=\"mds-targets mds-reveal d1\">\n        <div class=\"mds-target\"><div class=\"mds-target-ico\">&#x1f3e5;<\/div><div class=\"mds-target-text\">Ricercatori clinici e team ospedalieri che progettano il loro studio<\/div><\/div>\n        <div class=\"mds-target\"><div class=\"mds-target-ico\">&#x1f3ed;<\/div><div class=\"mds-target-text\">Aziende pharma e biotech con SAP da produrre per submission EMA\/FDA<\/div><\/div>\n        <div class=\"mds-target\"><div class=\"mds-target-ico\">&#x1f52c;<\/div><div class=\"mds-target-text\">IRCCS e centri di ricerca con studi multicentrici in fase di avvio<\/div><\/div>\n        <div class=\"mds-target\"><div class=\"mds-target-ico\">&#x1f4cb;<\/div><div class=\"mds-target-text\">Chi ha un protocollo abbozzato e vuole un second opinion prima del comitato etico<\/div><\/div>\n      <\/div>\n    <\/div>\n  <\/section>\n\n  <!-- COME FUNZIONA -->\n  <section class=\"mds-s5\">\n    <div class=\"mds-s5-wrap\">\n      <div class=\"mds-s5-left mds-reveal\">\n        <div class=\"mds-eyebrow\">Come funziona<\/div>\n        <h2 class=\"mds-title lg\">Dal primo contatto al <em>protocollo pronto.<\/em><\/h2>\n        <p>Inizia con una descrizione del tuo progetto: obiettivo, popolazione, tipo di studio, vincoli temporali e regolatori. Rispondiamo entro 24 ore con una valutazione preliminare e una proposta di lavoro.<\/p>\n        <p><em>Non ti chiediamo di sapere gi\u00e0 cosa ti serve. Ti chiediamo di descriverci il problema \u2014 pensiamo noi a come risolverlo.<\/em><\/p>\n        <div class=\"mds-s5-btns\">\n          <a class=\"mds-btn solid\" href=\"https:\/\/www.mathsly.it\/wordpress\/contatti\/\">Parliamo del tuo studio<\/a>\n          <a class=\"mds-btn outline\" href=\"https:\/\/www.mathsly.it\/wordpress\/prenotazione-appuntamento\/\">Prenota una call \u2192<\/a>\n        <\/div>\n      <\/div>\n      <div class=\"mds-steps mds-reveal d1\">\n        <div class=\"mds-step\">\n          <span class=\"mds-step-n\">01<\/span>\n          <div><div class=\"mds-step-title\">Descrivi il progetto<\/div><div class=\"mds-step-desc\">Obiettivo, tipo di studio, popolazione, dati disponibili e vincoli. Anche in forma preliminare \u2014 non serve avere tutto chiaro.<\/div><\/div>\n        <\/div>\n        <div class=\"mds-step\">\n          <span class=\"mds-step-n\">02<\/span>\n          <div><div class=\"mds-step-title\">Valutiamo entro 24h<\/div><div class=\"mds-step-desc\">Risposta con valutazione preliminare, impostazione metodologica proposta e preventivo. Gratuito e senza impegno.<\/div><\/div>\n        <\/div>\n        <div class=\"mds-step\">\n          <span class=\"mds-step-n\">03<\/span>\n          <div><div class=\"mds-step-title\">Lavoriamo insieme<\/div><div class=\"mds-step-desc\">Protocollo, SAP e tutti i deliverable pre-specificati, condivisi e revisionati insieme. Codice documentato, output difendibili.<\/div><\/div>\n        <\/div>\n      <\/div>\n    <\/div>\n  <\/section>\n\n  <!-- TRE LINEE -->\n  <section class=\"mds-s6\">\n    <div class=\"mds-s6-wrap\">\n      <div class=\"mds-s6-head mds-reveal\">\n        <div class=\"mds-eyebrow center\">Le tre linee Mathsly<\/div>\n        <h2 class=\"mds-title lg\">Ogni studio ha la sua fase critica. <em>Noi siamo l\u00e0 in ognuna.<\/em><\/h2>\n      <\/div>\n      <div class=\"mds-lines\">\n        <div class=\"mds-line-card active mds-reveal\">\n          <div class=\"mds-line-n\">\u2460 Design<\/div>\n          <div class=\"mds-line-name\">Mathsly Design<\/div>\n          <div class=\"mds-line-claim\">&#8220;Progettiamo lo studio prima che i dati esistano.&#8221;<\/div>\n          <div class=\"mds-line-arr\">Sei qui<\/div>\n        <\/div>\n        <a class=\"mds-line-card mds-reveal d1\" href=\"https:\/\/www.mathsly.it\/wordpress\/mathsly-analysis\/\">\n          <div class=\"mds-line-n\">\u2461 Analysis<\/div>\n          <div class=\"mds-line-name\">Mathsly Analysis<\/div>\n          <div class=\"mds-line-claim\">&#8220;Analizziamo i tuoi dati con la metodologia che regge alla peer review.&#8221;<\/div>\n          <div class=\"mds-line-arr\">Scopri \u2192<\/div>\n        <\/a>\n        <a class=\"mds-line-card mds-reveal d2\" href=\"https:\/\/www.mathsly.it\/wordpress\/mathsly-review\/\">\n          <div class=\"mds-line-n\">\u2462 Review<\/div>\n          <div class=\"mds-line-name\">Mathsly Review<\/div>\n          <div class=\"mds-line-claim\">&#8220;Prepariamo la risposta ai reviewer prima che diventi un problema.&#8221;<\/div>\n          <div class=\"mds-line-arr\">Scopri \u2192<\/div>\n        <\/a>\n      <\/div>\n    <\/div>\n  <\/section>\n\n  <!-- CTA -->\n  <section class=\"mds-s7\" style=\"position:relative;\">\n    <div class=\"mds-s7-bar\"><\/div>\n    <div class=\"mds-s7-wrap\">\n      <div class=\"mds-eyebrow light center mds-reveal\">Parliamo del tuo progetto<\/div>\n      <h2 class=\"mds-title lg mds-reveal d1\">Il tuo studio merita una <em>base solida.<\/em><\/h2>\n      <p class=\"mds-reveal d1\">Descrivi il progetto \u2014 obiettivo, tipo di studio, vincoli temporali. Valutiamo e rispondiamo entro 24 ore. Il preventivo \u00e8 gratuito.<\/p>\n      <div class=\"mds-s7-btns mds-reveal d2\">\n        <a class=\"mds-btn solid\" href=\"https:\/\/www.mathsly.it\/wordpress\/contatti\/\">Parliamo del tuo studio<\/a>\n        <a class=\"mds-btn outline-light\" href=\"https:\/\/www.mathsly.it\/wordpress\/prenotazione-appuntamento\/\">Prenota una call<\/a>\n      <\/div>\n    <\/div>\n  <\/section>\n\n<\/div>\n\n<script>\n(function(){\n  var io = new IntersectionObserver(function(e){ e.forEach(function(x){ if(x.isIntersecting){ x.target.classList.add(\"up\"); io.unobserve(x.target); } }); }, { threshold: 0.07 });\n  document.querySelectorAll(\".mds-reveal:not(.mds-lcp)\").forEach(function(el){ io.observe(el); });\n})();\n<\/script>\n","protected":false},"excerpt":{"rendered":"<p>Mathsly Design \u00e8 il servizio di Mathsly Research dedicato alla progettazione statistica di studi clinici e di ricerca. Deliverable: definizione endpoint ed estimand ICH E9(R1), scelta disegno (RCT, osservazionale, RWE, crossover, adattivo), calcolo sample size per submission EMA\/FDA, redazione protocollo (CONSORT, STROBE, PRISMA, ICH E6), Statistical Analysis Plan (SAP) pre-specificato con missing data, sensitivity analysis &#8230; <a title=\"Mathsly Design\" class=\"read-more\" href=\"https:\/\/www.mathsly.it\/wordpress\/mathsly-design\/\" aria-label=\"Per saperne di pi\u00f9 su Mathsly Design\">Leggi tutto<\/a><\/p>\n","protected":false},"author":138,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-24599","page","type-page","status-publish"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.3 (Yoast SEO v28.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Mathsly Design \u2014 Progettazione studi clinici e SAP - Mathsly Research<\/title>\n<meta name=\"description\" content=\"Progettiamo studi clinici prima che i dati esistano. 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