{"id":24892,"date":"2026-06-27T16:56:41","date_gmt":"2026-06-27T14:56:41","guid":{"rendered":"https:\/\/www.mathsly.it\/wordpress\/?page_id=24892"},"modified":"2026-07-23T15:49:04","modified_gmt":"2026-07-23T13:49:04","slug":"protocolli-ricerca-sap","status":"publish","type":"page","link":"https:\/\/www.mathsly.it\/wordpress\/protocolli-ricerca-sap\/","title":{"rendered":"Protocolli di Ricerca e SAP \u2014 Statistical Analysis Plan ICH E9(R1)"},"content":{"rendered":"\n<!-- ============================================================\n  MATHSLY RESEARCH \u2014 Protocolli di Ricerca e SAP\n  Luglio 2026: Fraunces, hero navy\n============================================================ -->\n\n<link rel=\"preconnect\" href=\"https:\/\/fonts.googleapis.com\">\n<link rel=\"preconnect\" href=\"https:\/\/fonts.gstatic.com\" crossorigin=\"\">\n<link href=\"https:\/\/fonts.googleapis.com\/css2?family=Fraunces:ital,opsz,wght@0,9..144,400;0,9..144,600;0,9..144,700;1,9..144,400;1,9..144,600;1,9..144,700&amp;family=DM+Sans:wght@300;400;500;600&amp;display=swap\" rel=\"stylesheet\">\n\n<style>\n.msap *, .msap *::before, .msap *::after { box-sizing: border-box; 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}\n}\n<\/style>\n\n<div class=\"msap\">\n  <p class=\"msap-geo\">Mathsly Research redige protocolli di ricerca e Statistical Analysis Plan (SAP) per studi clinici, osservazionali e RWE. Conformit\u00e0 ICH E9(R1), ICH E6 GCP, EMA e FDA. SAP per comitati etici, submission regolatorie e IDMC\/DSMB. H-index 13 Scopus. Risposta entro 24 ore.<\/p>\n\n  <!-- HERO (navy) -->\n  <section class=\"msap-s1\">\n    <div class=\"msap-s1-bar\"><\/div>\n    <div class=\"msap-s1-glow a\"><\/div>\n    <div class=\"msap-s1-glow b\"><\/div>\n    <div class=\"msap-s1-wrap\">\n      <div>\n        <div class=\"msap-eyebrow msap-reveal\" style=\"color:rgba(34,159,164,.75);\">Protocolli di Ricerca e SAP<\/div>\n        <h1 class=\"msap-title hero msap-s1-title msap-lcp\">Il piano metodologico che <em>regge a qualsiasi scrutinio.<\/em><\/h1>\n        <p class=\"msap-s1-sub msap-reveal d1\">Protocolli di studio e Statistical Analysis Plan per studi clinici, osservazionali e RWE. Per comitati etici, submission EMA e FDA, e IDMC\/DSMB \u2014 con la stessa coerenza metodologica dall&#8217;inizio alla fine.<\/p>\n        <div class=\"msap-s1-btns msap-reveal d2\">\n          <a class=\"msap-btn solid\" href=\"https:\/\/www.mathsly.it\/wordpress\/contatti\/\">Richiedi un preventivo<\/a>\n          <a class=\"msap-btn outline-white\" href=\"https:\/\/www.mathsly.it\/wordpress\/prenotazione-appuntamento\/\">Prenota una call \u2192<\/a>\n        <\/div>\n      <\/div>\n      <div class=\"msap-diff-list msap-reveal d1\">\n        <div class=\"msap-diff-item\">\n          <div class=\"msap-diff-ico\">&#x1f4cb;<\/div>\n          <div>\n            <div class=\"msap-diff-name\">Pre-specificazione completa<\/div>\n            <div class=\"msap-diff-desc\">Ogni analisi definita prima di vedere i dati \u2014 endpoint, popolazioni, metodi, missing data. Nessuna ambiguit\u00e0 in sede di revisione o ispezione.<\/div>\n          <\/div>\n        <\/div>\n        <div class=\"msap-diff-item\">\n          <div class=\"msap-diff-ico\">&#x26a1;<\/div>\n          <div>\n            <div class=\"msap-diff-name\">SAP in 3\u20137 giorni in urgenza<\/div>\n            <div class=\"msap-diff-desc\">Per deadline regolatorie o submission imminenti. Standard 7\u201314 giorni. Primo feedback entro 24 ore dalla richiesta.<\/div>\n          <\/div>\n        <\/div>\n        <div class=\"msap-diff-item\">\n          <div class=\"msap-diff-ico\">&#x1f6e1;&#xfe0f;<\/div>\n          <div>\n            <div class=\"msap-diff-name\">Conformit\u00e0 ICH E9(R1) e framework estimand<\/div>\n            <div class=\"msap-diff-desc\">SAP allineato all&#8217;addendum estimand \u2014 intercurrent events, strategie di gestione e population-level summary \u2014 per trial moderni e dossier regolatori.<\/div>\n          <\/div>\n        <\/div>\n      <\/div>\n    <\/div>\n  <\/section>\n\n  <!-- KPI BAR -->\n  <div class=\"msap-kpi\">\n    <div class=\"msap-kpi-inner\">\n      <div class=\"msap-kpi-item\"><div class=\"msap-kpi-val\">7\u201314 giorni \u00b7 3\u20137 urgenza<\/div><div class=\"msap-kpi-label\">Consegna SAP<\/div><\/div>\n      <div class=\"msap-kpi-item\"><div class=\"msap-kpi-val\">ICH E9(R1) \u00b7 EMA \u00b7 FDA<\/div><div class=\"msap-kpi-label\">Standard regolatori<\/div><\/div>\n      <div class=\"msap-kpi-item\"><div class=\"msap-kpi-val\">CE \u00b7 IDMC \u00b7 Submission<\/div><div class=\"msap-kpi-label\">Tutti i contesti di utilizzo<\/div><\/div>\n      <div class=\"msap-kpi-item\"><div class=\"msap-kpi-val\">Entro 24h<\/div><div class=\"msap-kpi-label\">Primo feedback garantito<\/div><\/div>\n    <\/div>\n  <\/div>\n\n  <!-- INTRO -->\n  <section class=\"msap-s2\">\n    <div class=\"msap-s2-wrap\">\n      <div class=\"msap-s2-left msap-reveal\">\n        <div class=\"msap-eyebrow\">Perch\u00e9 il SAP \u00e8 critico<\/div>\n        <h2 class=\"msap-title lg\">Un errore nel piano di analisi <em>non si recupera dopo.<\/em><\/h2>\n        <p>Il Statistical Analysis Plan non \u00e8 un documento burocratico \u2014 \u00e8 il contratto metodologico dello studio. Definisce in anticipo come verranno analizzati i dati, quali popolazioni, quali test, come si gestiscono i missing. Se redatto dopo aver visto i risultati, perde tutta la sua credibilit\u00e0.<\/p>\n        <p>Revisori, comitati etici e agenzie regolatorie lo leggono con attenzione. Un SAP vago, incoerente con il protocollo o non allineato a ICH E9(R1) \u00e8 uno dei motivi pi\u00f9 comuni di richieste di chiarimento o rigetto in submission.<\/p>\n      <\/div>\n      <div class=\"msap-when-cards\">\n        <div class=\"msap-when-card msap-reveal\">\n          <div class=\"msap-when-ico\">&#x1f3db;&#xfe0f;<\/div>\n          <div>\n            <div class=\"msap-when-title\">Submission a comitato etico<\/div>\n            <p class=\"msap-when-desc\">Protocollo completo con sezione statistica dettagliata: obiettivi, disegno, campionamento, power analysis, endpoint e piano di analisi \u2014 nella forma richiesta dal CE italiano o internazionale.<\/p>\n          <\/div>\n        <\/div>\n        <div class=\"msap-when-card msap-reveal d1\">\n          <div class=\"msap-when-ico\">&#x1f30d;<\/div>\n          <div>\n            <div class=\"msap-when-title\">Regulatory submission EMA e FDA<\/div>\n            <p class=\"msap-when-desc\">SAP conforme a ICH E9(R1) con framework estimand, gestione degli intercurrent events e sensitivity analysis pre-specificate. Pronto per essere allegato al dossier regolatorio.<\/p>\n          <\/div>\n        <\/div>\n        <div class=\"msap-when-card msap-reveal d2\">\n          <div class=\"msap-when-ico\">&#x1f6e1;&#xfe0f;<\/div>\n          <div>\n            <div class=\"msap-when-title\">IDMC e analisi ad interim<\/div>\n            <p class=\"msap-when-desc\">SAP specifico per Independent Data Monitoring Committee: analisi intermedie pre-definite, stopping rules e boundaries (O&#8217;Brien-Fleming, Lan-DeMets), con DMC Charter \u2014 sezione statistica.<\/p>\n          <\/div>\n        <\/div>\n        <div class=\"msap-when-card msap-reveal d3\">\n          <div class=\"msap-when-ico\">&#x1f4f0;<\/div>\n          <div>\n            <div class=\"msap-when-title\">Pubblicazione su riviste peer-reviewed<\/div>\n            <p class=\"msap-when-desc\">SAP registrato prima della raccolta dati, coerente con CONSORT o STROBE \u2014 aumenta la credibilit\u00e0 della submission editoriale.<\/p>\n          <\/div>\n        <\/div>\n      <\/div>\n    <\/div>\n  <\/section>\n\n  <!-- SERVIZI (navy) -->\n  <section class=\"msap-s3\">\n    <div class=\"msap-s3-wrap\">\n      <div class=\"msap-s3-header msap-reveal\">\n        <div class=\"msap-eyebrow\" style=\"color:rgba(34,159,164,.70);\">Cosa facciamo<\/div>\n        <h2 class=\"msap-title lg\">Protocolli e SAP per <em>ogni tipo di studio.<\/em><\/h2>\n        <p>Dalla prima bozza del protocollo al SAP finale pronto per la submission \u2014 con coerenza metodologica garantita tra tutte le sezioni.<\/p>\n      <\/div>\n      <div class=\"msap-svc-grid\">\n        <div class=\"msap-svc-card msap-reveal\">\n          <div class=\"msap-svc-tag\">Protocollo di Studio<\/div>\n          <div class=\"msap-svc-title\">Redazione del protocollo di ricerca<\/div>\n          <ul class=\"msap-svc-list\">\n            <li>Definizione di obiettivi primari e secondari<\/li>\n            <li>Scelta e giustificazione del disegno di studio<\/li>\n            <li>Criteri di eleggibilit\u00e0, randomizzazione e stratificazione<\/li>\n            <li>Definizione operativa degli endpoint<\/li>\n            <li>Sezione statistica completa per submission CE<\/li>\n            <li>Conformit\u00e0 ICH E6(R2) GCP e linee guida EMA<\/li>\n          <\/ul>\n        <\/div>\n        <div class=\"msap-svc-card msap-reveal d1\">\n          <div class=\"msap-svc-tag\">SAP \u2014 Clinical Trial<\/div>\n          <div class=\"msap-svc-title\">Statistical Analysis Plan per trial clinici<\/div>\n          <ul class=\"msap-svc-list\">\n            <li>Framework estimand conforme a ICH E9(R1)<\/li>\n            <li>Definizione delle popolazioni (ITT, mITT, PP, safety set)<\/li>\n            <li>Pre-specificazione di tutte le analisi primarie e secondarie<\/li>\n            <li>Gestione missing data e sensitivity analysis<\/li>\n            <li>Analisi intermedie, stopping rules e DSMB charter<\/li>\n            <li>Conformit\u00e0 EMA e FDA \u2014 pronto per allegato al dossier<\/li>\n          <\/ul>\n        <\/div>\n        <div class=\"msap-svc-card msap-reveal d2\">\n          <div class=\"msap-svc-tag\">SAP \u2014 Studi Osservazionali e RWE<\/div>\n          <div class=\"msap-svc-title\">SAP per studi osservazionali e RWE<\/div>\n          <ul class=\"msap-svc-list\">\n            <li>Definizione della coorte e finestra temporale<\/li>\n            <li>Strategia di controllo del confounding (PSM, IPTW)<\/li>\n            <li>Gestione dei missing data in contesti osservazionali<\/li>\n            <li>Sensitivity analysis e analisi di robustezza<\/li>\n            <li>Conformit\u00e0 STROBE e RECORD per RWE su database<\/li>\n          <\/ul>\n        <\/div>\n      <\/div>\n      <div class=\"msap-svc-grid two\">\n        <div class=\"msap-svc-card msap-reveal\">\n          <div class=\"msap-svc-tag\">Power Analysis<\/div>\n          <div class=\"msap-svc-title\">Calcolo sample size<\/div>\n          <ul class=\"msap-svc-list\">\n            <li>Power analysis per endpoint primario e secondari<\/li>\n            <li>Adeguamento per drop-out, perdita al follow-up e non-compliance<\/li>\n            <li>Calcolo per disegni complessi (crossover, adattativi, cluster)<\/li>\n            <li>Simulazioni per studi con endpoint compositi o time-to-event<\/li>\n            <li>Documentazione dettagliata per submission CE e regolatoria<\/li>\n          <\/ul>\n        <\/div>\n        <div class=\"msap-svc-card msap-reveal d1\">\n          <div class=\"msap-svc-tag\">SAP \u2014 IDMC \u00b7 DSMB<\/div>\n          <div class=\"msap-svc-title\">SAP per IDMC e analisi ad interim<\/div>\n          <ul class=\"msap-svc-list\">\n            <li>Piano statistico specifico per Independent Data Monitoring Committee<\/li>\n            <li>Definizione delle analisi intermedie pre-specificate<\/li>\n            <li>Stopping rules e boundaries (O&#8217;Brien-Fleming, Lan-DeMets, Haybittle-Peto)<\/li>\n            <li>DMC Charter \u2014 sezione statistica<\/li>\n            <li>Report statistico riservato per le riunioni del comitato<\/li>\n          <\/ul>\n        <\/div>\n      <\/div>\n    <\/div>\n  <\/section>\n\n  <!-- TARGET -->\n  <section class=\"msap-s4\">\n    <div class=\"msap-s4-wrap\">\n      <div class=\"msap-s4-header msap-reveal\">\n        <div class=\"msap-eyebrow\">Per chi<\/div>\n        <h2 class=\"msap-title lg\">Due contesti, <em>stesso rigore.<\/em><\/h2>\n      <\/div>\n      <div class=\"msap-target-grid\">\n        <div class=\"msap-target-card msap-reveal\">\n          <div class=\"msap-target-tag\">PI e Medici Ricercatori<\/div>\n          <div class=\"msap-target-title\">Per chi progetta lo studio<\/div>\n          <ul class=\"msap-target-list\">\n            <li>Protocollo completo per submission al comitato etico italiano (CET\/CEL)<\/li>\n            <li>Sezione statistica per studi osservazionali no-profit<\/li>\n            <li>SAP per pubblicazione su riviste peer-reviewed<\/li>\n            <li>Registrazione su ClinicalTrials.gov o PROSPERO<\/li>\n            <li>Power analysis documentata per grant application<\/li>\n            <li>Advisory metodologico pre-submission CE<\/li>\n          <\/ul>\n        <\/div>\n        <div class=\"msap-target-card msap-reveal d1\">\n          <div class=\"msap-target-tag\">Pharma \u00b7 CRO \u00b7 Biotech<\/div>\n          <div class=\"msap-target-title\">Per chi gestisce trial regolatori<\/div>\n          <ul class=\"msap-target-list\">\n            <li>SAP conforme a ICH E9(R1) per trial di fase II\/III<\/li>\n            <li>Framework estimand e gestione intercurrent events<\/li>\n            <li>SAP per IDMC\/DSMB con stopping rules e boundaries<\/li>\n            <li>Integrazione con Clinical Study Report (CSR)<\/li>\n            <li>Supporto a submission EMA, FDA e AIFA<\/li>\n            <li>Revisione e audit di SAP gi\u00e0 redatti internamente<\/li>\n          <\/ul>\n        <\/div>\n      <\/div>\n    <\/div>\n  <\/section>\n\n  <!-- FAQ -->\n  <section class=\"msap-s5\">\n    <div class=\"msap-s5-wrap\">\n      <div class=\"msap-s5-left msap-reveal\">\n        <div class=\"msap-eyebrow\">FAQ<\/div>\n        <h2 class=\"msap-title lg\">Domande frequenti su <em>protocolli e SAP.<\/em><\/h2>\n        <p>Le domande pi\u00f9 comuni prima di avviare la redazione di un protocollo o di un SAP.<\/p>\n        <a class=\"msap-btn solid\" href=\"https:\/\/www.mathsly.it\/wordpress\/contatti\/\">Hai altre domande? Scrivici<\/a>\n      <\/div>\n      <div class=\"msap-faq msap-reveal d1\">\n        <div class=\"msap-faq-item\">\n          <div class=\"msap-faq-q\">Qual \u00e8 la differenza tra protocollo e SAP?<span class=\"msap-faq-ico\">+<\/span><\/div>\n          <div class=\"msap-faq-a\">Il protocollo definisce il disegno dello studio \u2014 obiettivi, popolazione, intervento, endpoint e procedura generale. Il SAP \u00e8 il documento tecnico che specifica in dettaglio come verranno analizzati i dati: metodi statistici, popolazioni analitiche, gestione dei missing, sensitivity analysis. Sono complementari: il SAP deve essere coerente con il protocollo ma va ben oltre la sezione statistica che il protocollo contiene.<\/div>\n        <\/div>\n        <div class=\"msap-faq-item\">\n          <div class=\"msap-faq-q\">Quando va redatto il SAP \u2014 prima o dopo la raccolta dati?<span class=\"msap-faq-ico\">+<\/span><\/div>\n          <div class=\"msap-faq-a\">Prima, sempre. Il SAP deve essere finalizzato e datato prima dell&#8217;apertura del database e dell&#8217;analisi dei dati. Redarlo dopo aver visto i risultati \u2014 anche parziali \u2014 compromette la credibilit\u00e0 dello studio agli occhi di revisori e agenzie regolatorie. Per gli studi pubblicati, la registrazione del SAP su ClinicalTrials.gov o PROSPERO prima della raccolta dati \u00e8 la pratica raccomandata.<\/div>\n        <\/div>\n        <div class=\"msap-faq-item\">\n          <div class=\"msap-faq-q\">Cosa \u00e8 il framework estimand e perch\u00e9 \u00e8 importante?<span class=\"msap-faq-ico\">+<\/span><\/div>\n          <div class=\"msap-faq-a\">L&#8217;estimand \u00e8 la quantit\u00e0 che lo studio intende stimare \u2014 definisce esattamente cosa si vuole misurare tenendo conto degli intercurrent events (es. drop-out, cambio terapia, morte). L&#8217;addendum ICH E9(R1) ha introdotto questo framework per rendere esplicita la domanda di ricerca e allineare disegno, analisi e interpretazione. EMA e FDA lo richiedono nei dossier regolatori moderni. Un SAP senza framework estimand \u00e8 oggi considerato incompleto in contesto regolatorio.<\/div>\n        <\/div>\n        <div class=\"msap-faq-item\">\n          <div class=\"msap-faq-q\">Potete revisionare un SAP gi\u00e0 redatto internamente?<span class=\"msap-faq-ico\">+<\/span><\/div>\n          <div class=\"msap-faq-a\">S\u00ec. L&#8217;audit di un SAP esistente \u00e8 uno dei servizi pi\u00f9 richiesti \u2014 soprattutto prima di una submission regolatoria o in risposta a richieste di chiarimento da parte di EMA o FDA. Verifichiamo coerenza con il protocollo, completezza secondo ICH E9(R1), adeguatezza dei metodi scelti e correttezza nella gestione dei missing data.<\/div>\n        <\/div>\n        <div class=\"msap-faq-item\">\n          <div class=\"msap-faq-q\">In quanto tempo consegnate un SAP?<span class=\"msap-faq-ico\">+<\/span><\/div>\n          <div class=\"msap-faq-a\">I tempi standard sono 7\u201314 giorni lavorativi per un SAP completo, a seconda della complessit\u00e0 dello studio. Per deadline regolatorie o submission imminenti, il servizio in urgenza garantisce consegna in 3\u20137 giorni. Il primo feedback sulla fattibilit\u00e0 e sui tempi viene fornito entro 24 ore dalla richiesta.<\/div>\n        <\/div>\n      <\/div>\n    <\/div>\n  <\/section>\n\n  <!-- CTA -->\n  <section class=\"msap-s6\">\n    <div class=\"msap-s6-wrap\">\n      <div class=\"msap-eyebrow msap-reveal\" style=\"justify-content:center; color:rgba(34,159,164,.70);\">Parliamo del tuo studio<\/div>\n      <h2 class=\"msap-title lg msap-reveal d1\">Hai uno studio da progettare o un SAP da <em>redigere?<\/em><\/h2>\n      <p class=\"msap-reveal d2\">Descrivici il contesto \u2014 tipo di studio, fase attuale e destinazione del SAP. Valutiamo in 24 ore e proponiamo un piano di lavoro su misura.<\/p>\n      <div class=\"msap-s6-btns msap-reveal d2\">\n        <a class=\"msap-btn solid-light\" href=\"https:\/\/www.mathsly.it\/wordpress\/contatti\/\">Richiedi un preventivo<\/a>\n        <a class=\"msap-btn outline-light\" href=\"https:\/\/www.mathsly.it\/wordpress\/prenotazione-appuntamento\/\">Prenota una call<\/a>\n      <\/div>\n      <div class=\"msap-related msap-reveal d3\">\n        <span class=\"msap-related-label\">Vedi anche<\/span>\n        <a class=\"msap-related-link\" href=\"https:\/\/www.mathsly.it\/wordpress\/biostatistica-studi-clinici\/\">Biostatistica e Studi Clinici<\/a>\n        <a class=\"msap-related-link\" href=\"https:\/\/www.mathsly.it\/wordpress\/advisory-metodologico-indipendente\/\">Advisory Indipendente<\/a>\n        <a class=\"msap-related-link\" href=\"https:\/\/www.mathsly.it\/wordpress\/medical-writing\/\">Medical Writing<\/a>\n        <a class=\"msap-related-link\" href=\"https:\/\/www.mathsly.it\/wordpress\/servizi\/\">Tutti i servizi<\/a>\n      <\/div>\n    <\/div>\n  <\/section>\n<\/div>\n\n<script>\n(function(){\n  var io = new IntersectionObserver(function(entries){\n    entries.forEach(function(e){\n      if(e.isIntersecting){ e.target.classList.add(\"up\"); io.unobserve(e.target); }\n    });\n  }, { threshold: 0.07 });\n  document.querySelectorAll(\".msap-reveal\").forEach(function(el){ io.observe(el); });\n  document.querySelectorAll(\".msap-faq-item\").forEach(function(item){\n    item.querySelector(\".msap-faq-q\").addEventListener(\"click\", function(){\n      var isOpen = item.classList.contains(\"open\");\n      document.querySelectorAll(\".msap-faq-item\").forEach(function(i){ i.classList.remove(\"open\"); });\n      if(!isOpen) item.classList.add(\"open\");\n    });\n  });\n})();\n<\/script>\n","protected":false},"excerpt":{"rendered":"<p>Mathsly Research redige protocolli di ricerca e Statistical Analysis Plan (SAP) per studi clinici, osservazionali e RWE. Conformit\u00e0 ICH E9(R1), ICH E6 GCP, EMA e FDA. SAP per comitati etici, submission regolatorie e IDMC\/DSMB. H-index 13 Scopus. Risposta entro 24 ore. Protocolli di Ricerca e SAP Il piano metodologico che regge a qualsiasi scrutinio. Protocolli &#8230; <a title=\"Protocolli di Ricerca e SAP \u2014 Statistical Analysis Plan ICH E9(R1)\" class=\"read-more\" href=\"https:\/\/www.mathsly.it\/wordpress\/protocolli-ricerca-sap\/\" aria-label=\"Per saperne di pi\u00f9 su Protocolli di Ricerca e SAP \u2014 Statistical Analysis Plan ICH E9(R1)\">Leggi tutto<\/a><\/p>\n","protected":false},"author":138,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-24892","page","type-page","status-publish"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.7 (Yoast SEO v28.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Protocolli di Ricerca e SAP \u2014 Statistical Analysis Plan ICH E9(R1) - Mathsly Research<\/title>\n<meta name=\"description\" content=\"Protocolli di studio e Statistical Analysis Plan per trial clinici, studi osservazionali e IDMC. Consegna in 7\u201314 giorni, urgenza in 3\u20137.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.mathsly.it\/wordpress\/protocolli-ricerca-sap\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Protocolli di Ricerca e SAP \u2014 Statistical Analysis Plan ICH E9(R1) - Mathsly Research\" \/>\n<meta property=\"og:description\" content=\"Mathsly Research redige protocolli di ricerca e Statistical Analysis Plan (SAP) per studi clinici, osservazionali e RWE. 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Consegna in 7\u201314 giorni, urgenza in 3\u20137.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.mathsly.it\/wordpress\/protocolli-ricerca-sap\/","og_locale":"it_IT","og_type":"article","og_title":"Protocolli di Ricerca e SAP \u2014 Statistical Analysis Plan ICH E9(R1) - Mathsly Research","og_description":"Mathsly Research redige protocolli di ricerca e Statistical Analysis Plan (SAP) per studi clinici, osservazionali e RWE. 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